Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly
| Autor: | John T. O'Brien, Richard J Porter, Elizabeth F. Marshall |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Cortisol secretion endocrine system medicine.medical_specialty Saliva Hydrocortisone Neuropsychological Tests Serotonergic Verbal learning 03 medical and health sciences 0302 clinical medicine Double-Blind Method Alzheimer Disease Internal medicine Blood plasma medicine Humans Learning Pharmacology (medical) 030212 general & internal medicine Aged Pharmacology Cross-Over Studies Verbal Behavior Tryptophan Association Learning Verbal Learning 030227 psychiatry Psychiatry and Mental health Memory Short-Term Endocrinology Area Under Curve Female Serotonin Psychology Psychomotor Performance Stress Psychological hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 16:73-78 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/026988110201600105 |
| Popis: | Serotonergic function is reduced in dementia of Alzheimer type (DAT) and abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis are also common. There is considerable interaction between the two systems. Effects of lowering brain serotonin on salivary and plasma cortisol were assessed in patients with DAT and in control subjects. A double-blind, cross-over design involving administration of two nutritionally balanced amino acid mixtures with or without tryptophan was used. Salivary and plasma cortisol were measured at intervals before and after the drink. DAT patients had higher salivary cortisol than controls. Despite a reduction of approximately 70% in plasma free tryptophan after 4 h in both groups, there was no effect on salivary or plasma cortisol. We conclude that, in subjects with DAT and healthy elderly subjects, acute tryptophan depletion had no effect on cortisol secretion. |
| Databáze: | OpenAIRE |
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