MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms
| Autor: | Yoichiro Isohama, Hiroaki Terasawa, Hideaki Matsushita, Masanori Hijioka, Shigeto Iwamoto, Akinori Hisatsune, Hiroshi Katsuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Internal capsule Anatomy and Physiology Mouse lcsh:Medicine Severity of Illness Index Diagnostic Radiology Behavioral Neuroscience Mice Internal Capsule Lateral Ventricles Neurobiology of Disease and Regeneration lcsh:Science Hematoma Multidisciplinary medicine.diagnostic_test Mortality rate Animal Models Magnetic Resonance Imaging medicine.anatomical_structure Anesthesia Cardiology Disease Progression Medicine Sensory Perception Radiology Research Article medicine.medical_specialty Histology Clinical Research Design Neuroimaging Neurological System Model Organisms Diagnostic Medicine Internal medicine Severity of illness medicine Animals Humans Animal Models of Disease Collagenases cardiovascular diseases Biology Survival analysis Cerebral Hemorrhage Injections Intraventricular Intracerebral hemorrhage Motor Systems business.industry lcsh:R Magnetic resonance imaging medicine.disease Survival Analysis nervous system diseases Mice Inbred C57BL Neuroanatomy Ventricle lcsh:Q business Psychomotor Performance Neuroscience |
| Zdroj: | PLoS ONE, Vol 8, Iss 7, p e67691 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Intracerebral hemorrhage (ICH) is featured by poor prognosis such as high mortality rate and severe neurological dysfunction. In humans, several valuables including hematoma volume and ventricular expansion of hemorrhage are known to correlate with the extent of mortality and neurological dysfunction. However, relationship between hematoma conditions and the severity of symptoms in animal ICH models has not been clarified. Here we addressed this issue by using 7-tesla magnetic resonance imaging (MRI) on collagenase-induced ICH model in mice. We found that the mortality rate and the performance in behavioral tests did not correlate well with the volume of hematoma. In contrast, when hemorrhage invaded the internal capsule, mice exhibited high mortality and showed poor sensorimotor performance. High mortality rate and poor performance in behavioral tests were also observed when hemorrhage invaded the lateral ventricle, although worsened symptoms associated with ventricular hemorrhage were apparent only during early phase of the disease. These results clearly indicate that invasion of the internal capsule or the lateral ventricle by hematoma is a critical determinant of poor prognosis in experimental ICH model in mice as well as in human ICH patients. MRI assessment may be a powerful tool to refine investigations of pathogenic mechanisms and evaluations of drug effects in animal models of ICH. |
| Databáze: | OpenAIRE |
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