Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: a meta-analysis
| Autor: | Jianping Liu, Yuhuai Wu, Zhaowei Teng, Yan Liu, Yun Zhu, Yinglu Hao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Neuropsychiatric Disease and Treatment carotid atherosclerosis 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Risk factor Stroke Original Research Cerebral infarction business.industry Odds ratio cerebral infarction medicine.disease Confidence interval meta-analysis Cerebral blood flow Meta-analysis Cardiology business 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s124386 |
| Popis: | Jianping Liu, Yun Zhu, Yuhuai Wu, Yan Liu, Zhaowei Teng, Yinglu Hao Department of Science and Education, Nephrology, Orthopedic and Cardiology, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, People’s Republic of China Abstract: Stroke, when poor blood flow to the brain results in cell death, is the third leading cause of disability and mortality worldwide, and appears as an unequal distribution in the global population. The cumulative risk of recurrence varies greatly up to 10 years after the first stroke. Carotid atherosclerosis is a major risk factor for stroke. The aim of this study was to investigate and estimate the relationship between carotid atherosclerosis and risk of stroke recurrence in the Chinese population. We performed a systematic review and meta-analysis of randomized controlled trials published from 2000 to 2013, using the following databases: PubMed, Embase, Medline, Wanfang, and the China National Knowledge Infrastructure. The odds ratios with 95% confidence intervals were calculated to examine this strength. A total of 22 studies, including 3,912 patients, 2,506 first-ever cases, and 1,406 recurrent cases, were pooled in this meta-analysis. Our results showed that the frequency of carotid atherosclerosis is higher in recurrent cases than that in the first-ever controls (78.88% vs 59.38%), and the statistical analysis demonstrated significant positive association between carotid atherosclerosis and recurrent cerebral infarction (odds ratio: 2.87; 95% confidence interval: 2.42–3.37; P |
| Databáze: | OpenAIRE |
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