Temporal learning among prefrontal and striatal ensembles
| Autor: | R. Austin. Bruce, Eric B. Emmons, Gabriela Tunes-Chiuffa, Jeeyu Choi, Nandakumar S. Narayanan, Matthew A. Weber, Youngcho Kim |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Corticostriatal circuits prefrontal cortex learning Dorsomedial striatum striatum Interval temporal logic fungi Striatum Biology Medial frontal cortex corticostriatal 03 medical and health sciences 030104 developmental biology 0302 clinical medicine General Earth and Planetary Sciences Fixed interval Premovement neuronal activity Original Article Prefrontal cortex Temporal learning Neuroscience 030217 neurology & neurosurgery General Environmental Science interval timing |
| Zdroj: | Cerebral Cortex Communications |
| DOI: | 10.1101/2020.02.28.970053 |
| Popis: | Behavioral flexibility requires the prefrontal cortex and striatum, but it is unclear if these structures play similar or distinct roles in adapting to novel circumstances. Here, we investigate neuronal ensembles in the medial frontal cortex (MFC) and the dorsomedial striatum (DMS) during one form of behavioral flexibility: learning a new temporal interval. We studied corticostriatal neuronal activity as rodents trained to respond after a 12-s fixed interval (FI12) learned to respond at a shorter 3-s fixed interval (FI3). On FI12 trials, we found that a key form of temporal processing—time-related ramping activity—decreased in the MFC but did not change in the DMS as animals learned to respond at a shorter interval. However, while MFC and DMS ramping was stable with successive days of two-interval performance, temporal decoding by DMS ensembles improved on FI3 trials. Finally, when comparing FI12 versus FI3 trials, we found that more DMS neurons than MFC neurons exhibited differential interval-related activity early in two-interval performance. These data suggest that the MFC and DMS play distinct roles during temporal learning and provide insight into corticostriatal circuits. |
| Databáze: | OpenAIRE |
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