Sentinel and non-sentinel lymph node metastases in patients with microinvasive breast cancer: a nationwide study
| Autor: | Emil Villiam Holm-Rasmussen, Niels Kroman, Maj-Britt Jensen, Tove Filtenborg Tvedskov, Eva Balslev |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Younger age Receptor ErbB-2 Denmark Sentinel lymph node Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biopsy medicine Humans In patient Registries Age of Onset Aged Retrospective Studies medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Human epidermal growth factor Incidence (epidemiology) Age Factors Middle Aged medicine.disease 030104 developmental biology Neoplasm Micrometastasis Lymphatic Metastasis 030220 oncology & carcinogenesis Female business Axillary staging |
| Zdroj: | Breast Cancer Research and Treatment. 175:713-719 |
| ISSN: | 1573-7217 0167-6806 |
| Popis: | To determine the incidence and risk factors of sentinel lymph node (SN) and non-SN metastases in patients with microinvasive breast cancer (MIBC, T1mic). This to identify MIBC patients in whom axillary staging can be safely omitted. The Danish Breast Cancer Group database was used to identify a total of 409 women with breast cancer ≤ 1 mm who underwent sentinel lymph node biopsy (SLNB) between 2002 and 2015. After validation, 233 patients were eligible for the analysis. The incidence rates of SN and non-SN metastases were determined. The associations between clinicopathological variables and a positive SN [pN1, pN1mi, or pN0(i+)] were analyzed using univariate and multivariate designs. Of 233 patients with MIBC, only 9 (3.9%) had SN macrometastases. An additional 18 (7.7%) and 23 (9.9%) had SN micrometastases and isolated tumor cells (ITCs), respectively. Of patients with SN macrometastases, two (22.2%) had non-SN macrometastases. In the adjusted analysis, a positive SN was associated with younger age (P = 0.0001) and a positive human epidermal growth factor 2 receptor (HER2) status (P = 0.03). The low incidence of SN macrometastases |
| Databáze: | OpenAIRE |
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