Influence of obesity on soluble endoglin and transforming growth factor β1 in women with polycystic ovary syndrome
| Autor: | Abdelaziz I. Amin, Ayman E. Ali, Nearmeen M. Rashad, Manar H. Soliman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:QH471-489 endocrine system diseases 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:Reproduction Diagnostic biomarker Soluble endoglin lcsh:R5-920 030219 obstetrics & reproductive medicine Receiver operating characteristic business.industry Case-control study nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Obesity Polycystic ovary female genital diseases and pregnancy complications Endocrinology Reproductive Medicine Obese subjects lcsh:Medicine (General) business Transforming growth factor |
| Zdroj: | Middle East Fertility Society Journal, Vol 23, Iss 4, Pp 418-424 (2018) |
| ISSN: | 1110-5690 |
| DOI: | 10.1016/j.mefs.2018.07.003 |
| Popis: | Background: Chronic low-grade inflammation is a common feature of obesity and polycystic ovary syndrome (PCOS). There is dysregulation of transforming growth factor (TGF)-β1 in women with PCOS, soluble endoglin (sEng) is a non-signaling coreceptor of the TGF-β modulating its responses. We aimed for the first time to investigate the impact of obesity on sEng and TGF-β1 in women with PCOS. Methods: Case control study enrolled seventy patients diagnosed with PCOS and50 control group. High sensitivity C-reactive protein (hs-CRP) and sEng levels were assessed using an enzyme-linked immunosorbent assay (ELISA). Results: Our results revealed that, PCOS patients had higher values of TGF-β1 and lower levels of sEng. Among both control and PCOS patients, obese subjects had higher values of TGF-β1 and lower levels of sEng. Receiver operating characteristic curve (ROC) analysis revealed that, the power of sEng was more sensitive and specific than TGF-β1 in diagnosis of PCOS and in differentiating obese from lean group. Nonetheless, the diagnostic power of both TGF-β1 and sEng was highly significant. Conclusion: Obese subjects of control and PCOS groups had higher values of TGF-β1 and lower values of plasma sEng level than lean subjects, the diagnostic power of both TGF-β1 and sEng was highly significant thus, sEng and TGF-β1 could be a useful diagnostic biomarker of PCOS. Keywords: Obesity, PCOS, TGF-β1, Soluble endoglin |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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