Genital inflammatory status and the innate immune response to contraceptive initiation

Autor:	Nina Radzey, Rushil Harryparsad, Bahiah Meyer, Pai Lien Chen, Xiaoming Gao, Charles Morrison, Ongeziwe Taku, Anna‐Lise Williamson, Celia Mehou‐Loko, Florence Lefebvre d'Hellencourt, Gregory Buck, Jennifer Smit, Jerome Strauss, Kavita Nanda, Khatija Ahmed, Mags Beksinska, Myrna Serrano, Veronique Bailey, Lindi Masson, Jennifer Deese
Rok vydání:	2022
Předmět:	Inflammation Immunology Obstetrics and Gynecology HIV Infections Levonorgestrel Medroxyprogesterone Acetate Intrauterine Devices Copper Immunity Innate Reproductive Medicine Contraceptive Agents Female Immunology and Allergy Cytokines Humans Female Genitalia
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989)REFERENCES. 88(2)
ISSN:	1600-0897
Popis:	Data on the effects of contraceptives on female genital tract (FGT) immune mediators are inconsistent, possibly in part due to pre-existing conditions that influence immune mediator changes in response to contraceptive initiation.This study included 161 South African women randomised to injectable depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD), or levonorgestrel (LNG) implant in the Evidence for Contraceptive Options and HIV Outcomes (ECHO) trial. We measured thirteen cytokines and antimicrobial peptides previously associated with HIV acquisition in vaginal swabs using Luminex and ELISA, before, and at 1 and 3 months after contraceptive initiation. Women were grouped according to an overall baseline inflammatory profile. We evaluated modification of the relationships between contraceptives and immune mediators by baseline inflammation, demographic, and clinical factors.Overall, LNG implant and copper IUD initiation were associated with increases in inflammatory cytokines, while no changes were observed following DMPA-IM initiation. However, when stratifying by baseline inflammatory profile, women with low baseline inflammation in all groups experienced significant increases in inflammatory cytokines, while those with a high baseline inflammatory profile experienced no change or decreases in inflammatory cytokines.We conclude that pre-contraceptive initiation immune profile modifies the effect of contraceptives on the FGT innate immune response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dfcdaaafa80f8f4214249743c83e3e https://pubmed.ncbi.nlm.nih.gov/35394678 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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