A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder
| Autor: | Sara E. Trace, Tammy L. Root, Laura M. Thornton, Paul Lichtenstein, Nancy L. Pedersen, Lauren Elizabeth Janson, Cynthia M. Bulik, Jessica H. Baker |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Alcohol use disorder Environment Genetic correlation Article Structural equation modeling Young Adult Risk Factors mental disorders Diseases in Twins Twins Dizygotic medicine Humans Bulimia Nervosa Psychiatry Biological Psychiatry Sweden Chi-Square Distribution Models Statistical Bulimia nervosa Twins Monozygotic Middle Aged Heritability medicine.disease Comorbidity Twin study Psychiatry and Mental health Female Psychology Alcohol-Related Disorders Chi-squared distribution Demography |
| Zdroj: | Psychiatry Research. 208:232-237 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2013.04.030 |
| Popis: | Bulimia nervosa (BN) and alcohol use disorder (AUD) frequently co-occur and may share genetic factors; however, the nature of their association is not fully understood. We assessed the extent to which the same genetic and environmental factors contribute to liability to BN and AUD. A bivariate structural equation model using a Cholesky decomposition was fit to data from 7241 women who participated in the Swedish Twin study of Adults: Genes and Environment. The proportion of variance accounted for by genetic and environmental factors for BN and AUD and the genetic and environmental correlations between these disorders were estimated. In the best-fitting model, the heritability estimates were 0.55 (95% CI: 0.37; 0.70) for BN and 0.62 (95% CI: 0.54; 0.70) for AUD. Unique environmental factors accounted for the remainder of variance for BN. The genetic correlation between BN and AUD was 0.23 (95% CI: 0.01; 0.44), and the correlation between the unique environmental factors for the two disorders was 0.35 (95% CI: 0.08; 0.61), suggesting moderate overlap in these factors. The findings from this investigation provide additional support that some of the same genetic factors may influence liability to both BN and AUD. |
| Databáze: | OpenAIRE |
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