Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins

Autor: Carlos Hugo-Martínez, Gala Freixer, Khaoula Zekri-Nechar, Mariano de la Serna-Soto, José J. Zamorano-León, Ferrán Plá-Sanchez, Rodrigo Rial, Javier Serrano, Guillermo Moñux, Antonio J. López-Farré, Antonio Segura
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Nitric Oxide Synthase Type III
Endothelium
medicine.medical_treatment
Pilot Projects
Inflammation
Compression stockings
030204 cardiovascular system & hematology
medicine.disease_cause
Gastroenterology
Varicose Veins
03 medical and health sciences
0302 clinical medicine
Internal medicine
Varicose veins
medicine
Humans
Saphenous Vein
030212 general & internal medicine
Vein
Blood Coagulation
biology
Interleukin-6
business.industry
Middle Aged
medicine.disease
Thrombosis
Interleukin-10
Nitric oxide synthase
Oxidative Stress
Treatment Outcome
medicine.anatomical_structure
Venous Insufficiency
Factor Xa
NADPH Oxidase 2
biology.protein
Female
Surgery
Inflammation Mediators
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Vascular Surgical Procedures
Biomarkers
Stockings
Compression
Oxidative stress
Zdroj: Journal of Vascular Surgery: Venous and Lymphatic Disorders. 9:428-434
ISSN: 2213-333X
DOI: 10.1016/j.jvsv.2020.05.020
Popis: The objective of this study was to analyze whether compression stocking therapy in the human varicose vein wall may change the levels of biomarkers associated with vein insufficiency.Dilated collateral varicose vein samples were obtained from patients showing chronic venous disease (class 2 of the Clinical, Etiology, Anatomy, and Pathophysiology classification). Before elective surgery, 12 patients underwent compression stocking therapy (for 1 month) and 9 patients did not (control group). Expression levels of biomarkers associated with endothelial functionality (nitric oxide synthase 3), inflammation (interleukin-6, interleukin-10), oxidative stress (Gp91Compression stockings increased the content of nitric oxide synthase 3 (control, 16.48 [16.04-17.40] AU; compression, 83.71 [67.70-91.85] AU; P .001) in the varicose vein wall that was accompanied by reduction of both interleukin-6 levels (control, 38.72 [33.48-48.52] pg/μg protein; compression, 14.49 [11.05-17.41] pg/μg protein; P = .001) and the expression of Gp91In the varicose vein wall, compression stocking therapy improved the content levels of biomarkers associated with endothelial functionality, inflammation, oxidative stress, and coagulation.
Databáze: OpenAIRE
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