Stroke as a late sequela of cranial irradiation for childhood brain tumors
| Autor: | Stuart M. Siegel, Lawrence S. Fishman, John H. Miller, Paul M. Zeltzer, Marvin D. Nelson, Daljit Soni, Wendy G. Mitchell |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine.artery medicine Humans Child Stroke Chemotherapy Radiotherapy business.industry Brain Neoplasms Microangiopathy Sequela medicine.disease Craniopharyngioma Surgery Radiation therapy Stenosis Cerebrovascular Disorders Child Preschool Pediatrics Perinatology and Child Health Circle of Willis Female Neurology (clinical) business Tomography X-Ray Computed 030217 neurology & neurosurgery Carotid Artery Internal |
| Zdroj: | Journal of child neurology. 6(2) |
| ISSN: | 0883-0738 |
| Popis: | Cerebrovascular disease involving large and medium-size vessels is thought to be an uncommon sequela of treatment of childhood brain tumors. We reviewed 11 children who developed cerebrovascular disease manifested by strokes or transient ischemic attacks 6 months to 4 years after treatment of brain tumors, while their tumors were in remission. All had received radiation therapy, and seven had received chemotherapy. One child died of acute bilateral cerebral infarctions due to carotid occlusion on one side and marked stenosis on the other 2 years after receiving radiation therapy for an incompletely resected craniopharyngioma. Pathologically, there was marked subendothelial fibrosis of the vessels of the circle of Willis, with inflammatory changes surrounding some of the vessels. In addition to the widely recognized small-vessel damage caused by radiation and chemotherapy in children (mineralizing microangiopathy), damage to medium and large intracranial vessels may result in late sequelae, manifested by stroke or transient ischemic attacks. (J Child Neurol 1991;6:128-133). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|