Development of resistance to 2, 4-diamino-5(3'4'-dichlorphenyl)-6-methylpyrimidine (SK5265) by Streptococcus faecalis

Autor:	Dorris J. Hutchison, Georgia B. Waring, Joseph H. Burchenal
Rok vydání:	1953
Předmět:	Pyrimidine Streptococcus Liquid medium Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Microbiology chemistry.chemical_compound Pyrimidines Folic acid chemistry Resistant organism medicine Enterococcus faecalis Humans
Zdroj:	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 82(3)
ISSN:	0037-9727
Popis:	Summary1. By growing S. faecalis (ATCC 8043) in a liquid medium containing successively higher concentrations of 2,4-diamino-5 (3'4'-dichlorphenyl)-6-methylpyrimidine (SK 5265), a thousand fold increase in resistance as evidenced by complete inhibition of growth and a more than two hundred thousand fold increase in resistance as demonstrated by the half maximum inhibition technic has been achieved. 2. No morphologic differences between the sensitive S. faecalis (8043) and the resistant variant could be detected. 3. The resistant organism has lost its requirement for supplementary PGA in Difco Folic Acid Assay Medium and certain other PGA deficient media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65db5dd534a931d3f019742fe6f1cbd4 https://pubmed.ncbi.nlm.nih.gov/13047456 Zobrazit plný text záznamu