Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function
| Autor: | Rodrigo Abensur Athanazio, Michelle Lisidati Franchini, Paulo Hilário Nascimento Saldiva, Bruce K. Rubin, Luís Fernando Amato-Lourenço, Naomi Kondo Nakagawa, Waldir Carreirão-Neto, Geraldo Lorenzi-Filho |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Mucociliary clearance Hypertension Pulmonary Pulmonary Fibrosis medicine.medical_treatment Critical Care and Intensive Care Medicine Humidifiers Pulmonary function testing Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Oxygen therapy medicine Humans Surface Tension 030212 general & internal medicine Aged Aged 80 and over Bronchiectasis Epidermal Growth Factor business.industry Macrophages Interleukin-8 Oxygen Inhalation Therapy Humidity Common cold Middle Aged Nasal Lavage Fluid medicine.disease Mucus Interleukin-10 Respiratory Function Tests Cough 030228 respiratory system Mucociliary Clearance Anesthesia Disease Progression Cytokines Nasal Lavage Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 150:407-414 |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2016.03.035 |
| Popis: | Background Little is known about the effects of long-term nasal low-flow oxygen (NLFO) on mucus and symptoms and how this variable is affected by dry or cold humidified gas. The aim of this study was to investigate the effects of dry-NLFO and cold bubble humidified-NLFO on nasal mucociliary clearance (MCC), mucus properties, inflammation, and symptoms in subjects with chronic hypoxemia requiring long-term domiciliary oxygen therapy. Methods Eighteen subjects (mean age, 68 years; 7 male; 66% with COPD) initiating NLFO were randomized to receive dry-NLFO (n = 10) or humidified-NLFO (n = 8). Subjects were assessed at baseline, 12 h, 7 days, 30 days, 12 months, and 24 months by measuring nasal MCC using the saccharin transit test, mucus contact angle (surface tension), inflammation (cells and cytokine concentration in nasal lavage), and symptoms according to the Sino-Nasal Outcome Test–20. Results Nasal MCC decreased significantly (40% longer saccharin transit times) and similarly in both groups over the study period. There was a significant association between impaired nasal MCC and decline in lung function. Nasal lavage revealed an increased proportion of macrophages, interleukin-8, and epidermal growth factor concentrations with decreased interleukin-10 during the study. No changes in the proportion of ciliated cells or contact angle were observed. Coughing and sleep symptoms decreased similarly in both groups. There were no outcome differences comparing dry vs cold bubble humidified NLFO. Conclusions In subjects receiving chronic NLFO, cold bubble humidification does not adequately humidify inspired oxygen to prevent deterioration of MCC, mucus hydration, and pulmonary function. The unheated bubble humidification performed no better than no humidification. Trial Registry ClinicalTrials.gov; No.: NCT02515786 ; URL: www.clinicaltrials.gov . |
| Databáze: | OpenAIRE |
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