Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes
| Autor: | Barbara T. Navé, George Davey Smith, C. L. Wang, Peter R. Shepherd, Susan E. Ozanne, Johannes B. Prins |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Monosaccharide Transport Proteins Insulin Receptor Substrate Proteins Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue Protein-Energy Malnutrition Phosphatidylinositol 3-Kinases chemistry.chemical_compound Pregnancy Physiology (medical) Internal medicine Insulin receptor substrate Adipocyte Adipocytes medicine Animals Insulin Lactation Rats Wistar Cells Cultured Epididymis biology Body Weight Glucose transporter Organ Size Phosphoproteins Rats Pregnancy Complications Phosphotransferases (Alcohol Group Acceptor) Insulin receptor Glucose Endocrinology Adipose Tissue chemistry Adipogenesis Prenatal Exposure Delayed Effects biology.protein Female Signal Transduction |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 273:E46-E51 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1997.273.1.e46 |
| Popis: | Insulin action on adipocytes was studied in the offspring of mothers who had been fed either a control (20% protein) or a low (8%)-protein diet during pregnancy and lactation. Adipocytes isolated from low-protein offspring had significantly higher basal and insulin-stimulated glucose uptakes than controls. This may be related to a threefold increase in insulin receptors in low-protein adipocytes. Consistent with these observed changes in glucose transport, adipocytes from low-protein animals had significantly higher basal and insulin-stimulated insulin receptor substrate (IRS)-1-associated phosphatidylinositol 3-kinase (PI 3-kinase) activities. There was also more p85-associated PI 3-kinase activity in these adipocytes. There was no difference in expression in the p85 regulatory subunit or the p110-alpha catalytic subunit of PI 3-kinase. In contrast, there was a sixfold reduction in the p110-beta catalytic subunit of PI 3-kinase in adipocytes from low-protein animals. These results suggest that poor fetal nutrition during pregnancy and lactation can have long-term effects on glucose transport and on the expression of key components of the insulin signaling pathway in adipocytes. |
| Databáze: | OpenAIRE |
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