The conservative physiology of the immune system
| Autor: | B. A. Verdolin, A.M.C. de Faria, Cláudia R. Carvalho, Nelson M. Vaz, A. Silva Neto, J. S. Menezes |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Molecular composition
Closure Physiology T-Lymphocytes T cell Immunology Biophysics Network Autoantigens Biochemistry Antigen-Antibody Reactions Immune system Autopoiesis medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Organism Autoantibodies Immunobiology lcsh:R5-920 biology General Neuroscience Models Immunological Autoantibody Cell Biology General Medicine Transplantation medicine.anatomical_structure lcsh:Biology (General) Panama blot biology.protein Antibody lcsh:Medicine (General) |
| Zdroj: | Brazilian Journal of Medical and Biological Research v.36 n.1 2003 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 36, Iss 1, Pp 13-22 (2003) Brazilian Journal of Medical and Biological Research, Volume: 36, Issue: 1, Pages: 13-22, Published: JAN 2003 |
| Popis: | Current immunological opinion disdains the necessity to define global interconnections between lymphocytes and regards natural autoantibodies and autoreactive T cells as intrinsically pathogenic. Immunological theories address the recognition of foreignness by independent clones of lymphocytes, not the relations among lymphocytes or between lymphocytes and the organism. However, although extremely variable in cellular/molecular composition, the immune system preserves as invariant a set of essential relations among its components and constantly enacts contacts with the organism of which it is a component. These invariant relations are reflected, for example, in the life-long stability of profiles of reactivity of immunoglobulins formed by normal organisms (natural antibodies). Oral contacts with dietary proteins and the intestinal microbiota also result in steady states that lack the progressive quality of secondary-type reactivity. Autoreactivity (natural autoantibody and autoreactive T cell formation) is also stable and lacks the progressive quality of clonal expansion. Specific immune responses, currently regarded as the fundament of the operation of the immune system, may actually result from transient interruptions in this stable connectivity among lymphocytes. More permanent deficits in interconnectivity result in oligoclonal expansions of T lymphocytes, as seen in Omenn's syndrome and in the experimental transplantation of a suboptimal diversity of syngeneic T cells to immunodeficient hosts, which also have pathogenic consequences. Contrary to theories that forbid autoreactivity as potentially pathogenic, the physiology of the immune system is conservative and autoreactive. Pathology derives from failures of these conservative mechanisms. |
| Databáze: | OpenAIRE |
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