Hepcidin and GDF15 in anemia of multiple myeloma
| Autor: | Guojin Wang, Shu-chong Mei, Zonghong Shao, Erbao Ruan, Limin Xing, Jia Song, Wen Qu, Yuhong Wu, Hong Liu, Jin Guan, Lijuan Li, Rong Fu, Xiaoming Wang, Huaquan Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Growth Differentiation Factor 15 Anemia Antineoplastic Agents Dexamethasone Bortezomib Hemoglobins Hepcidins Hepcidin hemic and lymphatic diseases Internal medicine medicine Humans RNA Messenger Multiple myeloma Aged Hematology biology Remission Induction Middle Aged medicine.disease Boronic Acids Gene Expression Regulation Neoplastic Endocrinology Erythropoietin Pyrazines Chronic Disease Ferritins Immunology Leukocytes Mononuclear biology.protein Female HAMP GDF15 Multiple Myeloma Anemia of chronic disease medicine.drug |
| Zdroj: | International Journal of Hematology. 100:266-273 |
| ISSN: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-014-1626-7 |
| Popis: | Multiple myeloma (MM) is a malignant disease of plasma cells and is often accompanied by anemia which may influence its progression and survival. The mechanism of anemia of chronic disease (ACD) in which iron homeostasis is impaired underlies that of MM-related anemia. In this study, we analyzed the role of hepcidin which is the main mediator of ACD and ACD-related cytokines in peripheral blood of MM patients. We showed that HAMP mRNA and growth differentiation factors 15 (GDF15) mRNA expressions in peripheral blood mononuclear cells (PBMCs) and plasma hepcidin, GDF15, interleukin-6 and erythropoietin in MM patients all increased significantly as compared to those in controls. In MM patients, the expression of HAMP mRNA showed a positive correlation with serum ferritin level, and a negative correlation with hemoglobin level. The levels of plasma hepcidin and GDF15 were significantly decreased in MM patients who achieved complete remission after six cycles VD (bortezomib + dexamethasone) regimen chemotherapy. These data indicated that overexpression of HAMP mRNA in PBMCs significantly correlated with increased plasma hepcidin level and may be involved in the pathogenesis of MM-related anemia. Furthermore, the levels of plasma hepcidin and GDF15 may be valuable in assessing the progress of MM. |
| Databáze: | OpenAIRE |
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