24-hour efficacy of travoprost/timolol BAK-free versus latanoprost/timolol fixed combinations in patients insufficiently controlled with latanoprost
| Autor: | Nikolaos D. Dragoumis, Theodoros Giannopoulos, Irini C. Voudouragkaki, Anna-Bettina Haidich, Kostantinos G. Boboridis, Alexandros K. Makridis, Malik Y. Kahook, Eleni Paschalinou, Anastasios G. P. Konstas |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure genetic structures Glaucoma Timolol chemistry.chemical_compound Tonometry Ocular Travoprost Ophthalmology medicine Humans Pharmacology (medical) Prospective Studies Latanoprost Antihypertensive Agents Intraocular Pressure Cross-Over Studies business.industry Drug Synergism General Medicine Middle Aged medicine.disease Crossover study eye diseases Drug Combinations Neuroprotective Agents Treatment Outcome Tolerability chemistry Prostaglandins F Synthetic Female sense organs Latanoprost/timolol Drug Monitoring business Glaucoma Open-Angle medicine.drug |
| Zdroj: | Advances in therapy. 31(6) |
| ISSN: | 1865-8652 |
| Popis: | To compare the 24-h intraocular pressure (IOP) control and tolerability of travoprost/timolol benzalkonium chloride (BAK)-free (TTFC) vs. latanoprost/timolol fixed combination preserved with BAK (LTFC) in open-angle glaucoma patients insufficiently controlled with latanoprost 0.005% monotherapy given once in the evening. The authors have conducted a prospective, observer-masked, active-controlled, cross-over, comparison study. Qualified open-angle glaucoma patients who demonstrated a latanoprost-treated morning IOP (10:00 ± 1 h) greater than 20 mmHg on two separate visits were randomized for 3 months to receive either TTFC or LTFC. Patients were then crossed over to the opposite treatment for another 3 months. At the end of the latanoprost run-in and after each 3-month therapy period patients underwent 24-h IOP monitoring in the habitual position using Goldmann applanation tonometry in the sitting position during the day (10:00, 14:00, 18:00 and 22:00) and Perkins tonometry in the supine position at night (02:00 and 06:00). Selected ocular surface parameters were evaluated after each therapy period. Forty-two open-angle glaucoma patients completed the study. The mean 24-h baseline IOP on latanoprost was 21.5 ± 1.6 mmHg. Both fixed combinations significantly reduced the IOP at each time point, for the mean, peak and fluctuation of 24-h IOP compared with latanoprost monotherapy (P |
| Databáze: | OpenAIRE |
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