Establishing Edoxaban’s Role in Anticoagulation
| Autor: | Yasmin Grace, Dimple Patel, Erenie Guirguis, Samantha Henningfield, Dana A. Brown |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pyridines medicine.drug_class Administration Oral 030204 cardiovascular system & hematology Dabigatran 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edoxaban medicine Humans Pharmacology (medical) 030212 general & internal medicine Intensive care medicine Blood Coagulation Stroke Clinical Trials as Topic Rivaroxaban business.industry Anticoagulant Warfarin Anticoagulants Atrial fibrillation Venous Thromboembolism medicine.disease Thiazoles chemistry Apixaban business Factor Xa Inhibitors medicine.drug |
| Zdroj: | Journal of Pharmacy Practice. 29:228-238 |
| ISSN: | 1531-1937 0897-1900 |
| DOI: | 10.1177/0897190016647314 |
| Popis: | Purpose This article serves as a review of the current literature regarding the role of edoxaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (AF) and the treatment of venous thromboembolism (VTE). Summary Until recent years, oral treatment options for both treatment and prevention of VTE and stroke were limited to warfarin. Dabigatran was the first new oral anticoagulant approved in over 50 years followed by rivaroxaban and apixaban. These new oral anticoagulants offer many benefits over warfarin. Edoxaban is the newest member among the oral anticoagulants and exerts its action by direct inhibition of factor Xa. It may offer some advantages in that it is the second Food and Drug Administration-approved once-daily anticoagulant available and does not interact with the cytochrome P450 (CYP450) system. However, there are concerns in patients with AF and preserved renal function (>95 mL/min), as these cohorts experienced a higher incidence of stroke in trials. Conclusion Based on the 3 clinical trials, edoxaban appears to be a safe and effective factor Xa inhibitor in patients with a creatinine clearance of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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