The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
| Autor: | Takahiro Hirabayashi, You Kumode, Shota Katori, Yasuo Uchiyama, Shun Hamada, Emi Fukuda, Peter Mombaerts, Shigeyuki Esumi, Takeshi Yagi, Sonoko Hasegawa |
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| Rok vydání: | 2007 |
| Předmět: |
Olfactory system
Male Mutant Protocadherin Sensory system Mice Transgenic Receptors Cell Surface Biology urologic and male genital diseases Receptors Odorant Olfactory Receptor Neurons Cellular and Molecular Neuroscience Mice Animals Receptor Molecular Biology Mice Inbred ICR urogenital system Gene targeting Cell Biology Olfactory Pathways respiratory system Cadherins Olfactory Bulb Axons Mice Mutant Strains Olfactory bulb Mice Inbred C57BL nervous system Multigene Family Gene Targeting Olfactory ensheathing glia Neuroscience Gene Deletion |
| Zdroj: | Molecular and cellular neurosciences. 38(1) |
| ISSN: | 1095-9327 |
| Popis: | Olfactory sensory neurons (OSNs) that express the same odorant receptor project their axons to specific glomeruli in the main olfactory bulb. Protocadherin-alpha (Pcdha) proteins, diverse cadherin-related molecules that are encoded as a gene cluster, are highly concentrated in OSN axons and olfactory glomeruli. Here, we describe Pcdha mutant mice, in which the constant region of the Pcdha gene cluster has been deleted by gene targeting. The mutant mice show abnormal sorting of OSN axons into glomeruli. There are multiple, small, extraneous glomeruli for the odorant receptors M71 and MOR23. These abnormal patterns of M71 and MOR23 glomeruli persist until adulthood. Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb. |
| Databáze: | OpenAIRE |
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