Serum uromodulin levels in prediction of acute kidney injury in the early phase of acute pancreatitis
| Autor: | Kuśnierz-Cabala, Beata, Gala-Błądzińska, Agnieszka, Mazur-Laskowska, Małgorzata, Dumnicka, Paulina, Sporek, Mateusz, Matuszyk, Aleksandra, Gil, Krzysztof, Ceranowicz, Piotr, Walocha, Jerzy, Kucharz, Jakub, Pędziwiatr, Michał, Bartuś, Krzysztof, Trąbka, Rafał, Kuźniewski, Marek |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Tamm–Horsfall protein acute pancreatitis uromodulin glycoproteins acute kidney injury 030232 urology & nephrology Pharmaceutical Science Renal function Urine Kidney Function Tests Gastroenterology Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Internal medicine Drug Discovery medicine Humans Physical and Theoretical Chemistry Creatinine biology Pancreatitis Acute Necrotizing business.industry Organic Chemistry Acute kidney injury Acute Kidney Injury Middle Aged medicine.disease chemistry Cystatin C Chemistry (miscellaneous) biology.protein Molecular Medicine Acute pancreatitis Female 030211 gastroenterology & hepatology Poland business Early phase Biomarkers Glomerular Filtration Rate |
| Zdroj: | Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules; Volume 22; Issue 6; Pages: 988 Molecules, Vol 22, Iss 6, p 988 (2017) |
| Popis: | In health, uromodulin is the main protein of urine. Serum uromodulin concentrations (sUMOD) have been shown to correlate with kidney function. Acute kidney injury (AKI) is among the main complications of severe acute pancreatitis (AP). No reports exist on sUMOD in patients with AP, including the diagnostic usefulness for early prediction of AP severity. We measured sUMOD during first 72 h of AP. Sixty-six adult patients with AP were recruited at the surgical ward of the District Hospital in Sucha Beskidzka, Poland. AP was diagnosed according to the Revised Atlanta Classification. Blood samples were collected at 24, 48 and 72 h of AP, and sUMOD concentrations were measured with enzyme-linked immunosorbent test. sUMOD decreased non-significantly during the study. Patients with severe AP had non-significantly lower sUMOD concentrations than those with mild disease. Significant positive correlation was observed between sUMOD and estimated glomerular filtration rate on each day of the study and negative correlations were shown between sUMOD and age, serum creatinine, cystatin C and urea. Patients with AKI tended to have lower sUMOD. Although sUMOD correlated significantly with kidney function in the early phase of AP, measuring sUMOD did not allow to reliably predict AP severity or development of AKI. |
| Databáze: | OpenAIRE |
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