Rocuronium pretreatment reduces suxamethonium-induced myalgia: comparison with vecuronium
| Autor: | G P Findlay, M J Spittal |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male myalgia Adolescent Neuromuscular Junction Succinylcholine Placebo Fentanyl Double-Blind Method Muscular Diseases medicine Humans Androstanols Prospective Studies Rocuronium Aged Pain Postoperative Vecuronium Bromide business.industry Middle Aged Drug interaction Surgery Oral Ketorolac Anesthesiology and Pain Medicine Neuromuscular Depolarizing Agents Anesthesia Morphine Female medicine.symptom Propofol business Preanesthetic Medication Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 76:526-529 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/76.4.526 |
| Popis: | We have studied, in 150 patients undergoing elective oral surgery, the effectiveness and sequelae of pretreatment with rocuronium for reducing myalgia after suxamethonium. Patients were allocated randomly to one of three groups: anaesthesia was induced with propofol and fentanyl, and group V received vecuronium 1 mg, group R rocuronium 6 mg and group P placebo pretreatment. Suxamethonium 1.5 mg kg-1 was given 60 s after the pretreatment agent. All patients received ketorolac 10 mg i.v. and morphine 10 mg i.m. for analgesia. The incidence of postoperative myalgia on day 1 after rocuronium (20%) was significantly less than after vecuronium (42%) (P0.05) or placebo (70%) (P0.01). By day 4 the incidence of myalgia was 28.6% in the rocuronium group, 46.3% in the vecuronium group and 95% in the placebo group. Intubating conditions were not affected adversely by any pretreatment regimen. |
| Databáze: | OpenAIRE |
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