Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis
| Autor: | Wannee Sukbangnop, Jitra Limthongkul, Vichai Reutrakul, Anowar Hosen, Patoomratana Tuchinda, Chutima Kuhakarn, Sariyarach Thanasansurapong, Chanita Napaswad, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Narong Nuntasaen, Suppisak Chaturonrutsamee, Sakchai Hongthong, Arthit Chairoungdua |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Stereochemistry
Anti-HIV Agents Phytochemicals Moderate activity 01 natural sciences Plant Roots Lignans chemistry.chemical_compound Combretaceae Cell Line Tumor Drug Discovery Humans Furans IC50 Tetrahydrofuran EC50 Pharmacology Anogeissus Syncytium biology Molecular Structure Plant Stems 010405 organic chemistry General Medicine biology.organism_classification Thailand Antineoplastic Agents Phytogenic Reverse transcriptase 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Reverse Transcriptase Inhibitors |
| Zdroj: | Fitoterapia. 151 |
| ISSN: | 1873-6971 |
| Popis: | Four previously undescribed tetrahydrofuran lignans, named anorisols A−D (1–4) and fourteen known compounds (5–18) were isolated from the roots, stems, leaves and twigs of Anogeissus rivularis. The chemical structures were elucidated on the basis of their spectroscopic data and by comparison with the literature data. The absolute configurations of 1–4 were established by comparison of the experimental ECD spectra with the calculated ECD spectra. Some isolated compounds were evaluated for their cytotoxic activity as well as anti-HIV-1 activity employing reverse transcriptase (RT) and syncytium reduction assays using the ΔTat/RevMC99 virus in 1A2 cell line systems. Compound 6 displayed the most potent activity in syncytium inhibition assay with effective concentration at 50% (EC50) value of 13.3 μM (SI >3.0). In the reverse transcriptase assay, compound 1 exhibited moderate activity with IC50 value of 213.9 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect