Nutritional prognostic scores in patients with hilar cholangiocarcinoma treated by percutaneous transhepatic biliary stenting combined with 125I seed intracavitary irradiation: A retrospective observational study
| Autor: | Wei Wang, Yong Wang, Zongkuang Li, Hao Jin, Zhongran Man, Zhen Qian, Xiaosi Hu, Lei Zhou, Peiyuan Cui, Song Yang, Huichun Liu, Qing Pang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Percutaneous Gastroenterology Cohort Studies Iodine Radioisotopes 0302 clinical medicine Liver Function Tests controlling nutritional status hilar cholangiocarcinoma Univariate analysis medicine.diagnostic_test General Medicine Middle Aged prognostic nutritional index Prognosis Combined Modality Therapy Biliary Tract Surgical Procedures 030220 oncology & carcinogenesis Female Stents Research Article Adult medicine.medical_specialty Nutritional Status Observational Study Sensitivity and Specificity 125I seed biliary stent 03 medical and health sciences Internal medicine medicine Humans Survival rate Survival analysis Aged Retrospective Studies Proportional hazards model business.industry Retrospective cohort study Survival Analysis 030104 developmental biology Nutrition Assessment Bile Duct Neoplasms ROC Curve Liver function tests business TBIL Follow-Up Studies Klatskin Tumor |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | We mainly aimed to preliminarily explore the prognostic values of nutrition-based prognostic scores in patients with advanced hilar cholangiocarcinoma (HCCA). We retrospectively analyzed 73 cases of HCCA, who underwent percutaneous transhepatic biliary stenting (PTBS) combined with 125I seed intracavitary irradiation from November 2012 to April 2017 in our department. The postoperative changes of total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and albumin (ALB) were observed. The preoperative clinical data were collected to calculate the nutrition-based scores, including controlling nutritional status (CONUT), C-reactive protein/albumin ratio (CAR), and prognostic nutritional index (PNI). Kaplan–Meier curve and Cox regression model were used for overall survival (OS) analyses. The serum levels of TBIL, DBIL, ALT, AST, and ALP significantly reduced, and ALB significantly increased at 1 month and 3 months postoperatively. The median survival time of the cohort was 12 months and the 1-year survival rate was 53.1%. Univariate analysis revealed that the statistically significant factors related to OS were CA19-9, TBIL, ALB, CONUT, and PNI. Multivariate analysis further identified CA19-9, CONUT, and PNI as independent prognostic factors. Nutrition-based prognostic scores, CONUT and PNI in particular, can be used as predictors of survival in unresectable HCCA. |
| Databáze: | OpenAIRE |
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