Reduction trend of mcr-1 circulation in Emilia-Romagna Region, Italy

Autor: Simone Ambretti, Chiara Bracchi, Vittorio Sambri, Carlo Biagetti, Adriana Calderaro, Claudia Venturelli, Giuseppe Diegoli, Ilaria Menozzi, Maria Federica Pedna, Martina Tambassi, Rossella Buttazzi, Carlo Gagliotti, Stefano Pongolini, Mario Sarti, Enrico Ricchizzi, Marianna Meschiari, Maria Luisa Moro, Erika Scaltriti, Massimo Confalonieri, Agostino Barozzi, Marina Morganti, Laura Soliani, Roberta Schiavo, Edoardo Carretto, Luca Bolzoni, Fabio Tumietto, Chiara Casadio
Přispěvatelé: Gagliotti C., Bolzoni L., Carretto E., Sarti M., Ricchizzi E., Ambretti S., Barozzi A., Bracchi C., Confalonieri M., Menozzi I., Morganti M., Pedna M.F., Sambri V., Scaltriti E., Schiavo R., Soliani L., Tambassi M., Venturelli C., Biagetti C., Buttazzi R., Calderaro A., Casadio C., Meschiari M., Tumietto F., Diegoli G., Pongolini S., Moro M.L.
Rok vydání: 2021
Předmět:
Microbiology (medical)
Veterinary medicine
Antimicrobials for veterinary use
Antibiotic resistance
Clonal dissemination
Klebsiella pneumoniae
Population
Drug Resistance
Horizontal transfer
Bacterial Protein
Microbial Sensitivity Tests
Minimum inhibitory concentration
Enterobacterales
One Health approach
Plasmid
Bacterial Proteins
Enterobacteriaceae
Enterobacterale
Anti-Bacterial Agent
Drug Resistance
Bacterial
medicine
Humans
Colistin
Mcr
Anti-Bacterial Agents
Enterobacteriaceae Infections
Ethanolaminephosphotransferase
Italy
Phylogeny
Retrospective Studies
education
education.field_of_study
biology
Microbial Sensitivity Test
Bacterial
General Medicine
biology.organism_classification
Enterobacteriaceae Infection
Infectious Diseases
Salmonella enterica
MCR-1
Enterobacter cloacae
hormones
hormone substitutes
and hormone antagonists
Human
medicine.drug
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases. 40:2585-2592
ISSN: 1435-4373
0934-9723
Popis: This study aims to describe trends of mcr-positive Enterobacterales in humans based on laboratory surveillance with a defined catchment population. The data source is the Micro-RER surveillance system, established in Emilia-Romagna region (Italy), to monitor the trend of mcr resistance. Enterobacterales isolates from human clinical samples with minimum inhibitory concentration (MIC) ≥ 2mg/L for colistin were sent to the study reference laboratory for the detection of mcr genes. Isolates prospectively collected in the period 2018–2020 were considered for the assessment of population rates and trends; further analyses were carried out for the evaluation of clonality and horizontal mcr gene transfer. Previous isolates from local laboratory collection were also described. In the period 2018–2020, 1164 isolates were sent to the reference laboratory, and 51 (4.4%) were confirmed as mcr-positive: 50 mcr-1 (42 Escherichia coli, 6 Klebsiella pneumoniae, 2 Salmonella enterica) and 1 mcr-4 (Enterobacter cloacae). The number of mcr-positive isolates dropped from 24 in the first half of 2018 to 3 in the whole of 2020 (trend p value < 0.001). Genomic analyses showed the predominant role of the horizontal transfer of mcr genes through plasmids or dissemination of transposable elements compared to clonal dissemination of mcr-positive microorganisms. The study results demonstrate a substantial decrease in the circulation of mcr-1 plasmid genes in Emilia-Romagna Region.
Databáze: OpenAIRE
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