Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
| Autor: | Laura A. Herndon, Peter J. Schmeissner, David H. Hall, Paula A. Brown, Yuko Sakano, Marie C. Paupard, Kristin M. Listner, Justyna M. Dudaronek, Monica Driscoll |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Nervous system
Aging Time Factors Longevity Biology medicine.disease_cause Green fluorescent protein Phosphatidylinositol 3-Kinases Genotype medicine Animals Humans Nervous System Physiological Phenomena Caenorhabditis elegans Caenorhabditis elegans Proteins Cellular Senescence Genes Helminth Neurons Genetics Stochastic Processes Mutation Multidisciplinary Muscles Reproduction Anatomy medicine.disease Phenotype medicine.anatomical_structure Gene Expression Regulation Organ Specificity Ageing Sarcopenia Ultrastructure Biomarkers Locomotion |
| Zdroj: | Nature. 419:808-814 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature01135 |
| Popis: | The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|