Retinol effects on CSF outflow through cultured human arachnoid granulation cells: implications for PTC
| Autor: | Martin Lubow, David W. Holman, Deborah M. Grzybowski |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Vitamin
medicine.medical_specialty Hematology Neurology endocrine system diseases business.industry Pseudotumor cerebri Retinol Arachnoid granulation medicine.disease lcsh:RC346-429 Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology medicine.anatomical_structure Developmental Neuroscience chemistry Internal medicine Etiology Medicine business lcsh:Neurology. Diseases of the nervous system Intracranial pressure |
| Zdroj: | Cerebrospinal Fluid Research, Vol 6, Iss Suppl 1, p S35 (2009) |
| ISSN: | 1743-8454 |
| DOI: | 10.1186/1743-8454-6-s1-s35 |
| Popis: | Background The underlying etiology of pseudotumor cerebri (PTC) remains unknown, however it has been estimated that an identifiable secondary cause is present in up to 10% of PTC cases. Of these secondary associations, vitamin A is of particular interest, as vitamin A toxicity is associated with an increased intracranial pressure similar to that seen in PTC. Recently, several clinical studies have suggested that serum and CSF retinol levels may be altered in PTC. We hypothesize that increased concentrations of retinoids in the CSF might increase resistance to CSF outflow at the arachnoid granulations (AGs). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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