Synergistic effects of gelatin and nanotopographical patterns on biomedical PCL patches for enhanced mechanical and adhesion properties
| Autor: | Taeseong Han, Sunho Park, Hoon Eui Jeong, Yubin Jeon, Yonghyun Gwon, Jangho Kim, Sujin Kim, Woochan Kim |
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| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Materials science Biocompatibility Polyesters Biomedical Engineering Biocompatible Materials 02 engineering and technology engineering.material Gelatin Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Coating Tensile Strength Ultimate tensile strength Tissue Engineering Tissue Scaffolds Biomaterial 030206 dentistry Adhesion 021001 nanoscience & nanotechnology Extracellular Matrix chemistry Mechanics of Materials Polycaprolactone engineering Adhesive 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of the mechanical behavior of biomedical materials. 114 |
| ISSN: | 1878-0180 |
| Popis: | Biomedical patches have been known as important biomaterial-based medical devices for the clinical treatment of tissue and organ diseases. Inspired by the extracellular matrix-like aligned nanotopographical pattern as well as the unique physical and biocompatible properties of gelatin, we developed strength-enhanced biomedical patches by coating gelatin onto the nanopatterned surface of polycaprolactone (PCL). The relative contributions of the nanotopographical pattern (physical factor) and gelatin coating (chemical factor) in enhancing the mechanical and adhesive properties of PCL were quantitatively investigated. The nanotopographical pattern increased the surface area of PCL, allowing more gelatin to be coated on its surface. The biomedical patch made from gelatin-coated nanopatterned PCL showed strong mechanical and adhesive properties (tensile strength: ~14.5 MPa; Young's modulus: ~60.2 MPa; and normal and shear adhesive forces: ~1.81 N/cm2 and ~352.3 kPa) as well as good biocompatibility. Although the nanotopographical pattern or gelatin coating alone could enhance these physical properties of PCL in both dry and wet environmental conditions, both factors in combination further strengthened the properties, indicating the importance of synergistic cues in driving the mechanical behavior of biomedical materials. This strength-enhanced biomedical patch will be especially useful for the treatment of tissues such as cartilage, tendon, and bone. |
| Databáze: | OpenAIRE |
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