Imaging mass spectrometry of elements in forensic cases by LA-ICP-MS
| Autor: | Marc Bollmann, Katarzyna Michaud, Raquel Vilarino, Max Villa, Estelle Lauer, Silke Grabherr, Aurélien Thomas, Marc Augsburger, Morgane Jotterand |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Trace Elements/analysis 0301 basic medicine Laser ablation inductively coupled plasma mass spectrometry Analytical chemistry Lasers Solid-State 01 natural sciences Mass Spectrometry Mass spectrometry imaging Pathology and Forensic Medicine 03 medical and health sciences Nuclear magnetic resonance La icp ms Skin/chemistry/pathology Humans Mass Spectrometry/methods Skin Histological examination Elemental composition Chemistry ddc:614.1 010401 analytical chemistry Middle Aged people.cause_of_death Trace Elements 0104 chemical sciences Electric Injuries Wounds Gunshot/pathology Electrocution 030104 developmental biology Tissue sections Electric Injuries/pathology Wounds Gunshot people |
| Zdroj: | International Journal of Legal Medicine, Vol. 131, No 2 (2017) pp. 497-500 |
| ISSN: | 1437-1596 0937-9827 |
| Popis: | Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was performed to map elements in thin formalin-fixed paraffin-embedded tissue sections of two forensic cases with firearm and electrocution injuries, respectively. In both cases, histological examination of the wounded tissue regions revealed the presence of exogenous aggregates that may be interpreted as metallic depositions. The use of imaging LA-ICP-MS allowed us to unambiguously determine the elemental composition of the observed aggregates assisting the pathologist in case assessments. To the best of our knowledge, we demonstrate for the first time the use of imaging LA-ICP-MS as a complementary tool for forensic pathologists and toxicologists in order to map the presence of metals and other elements in thin tissue sections of post-mortem cases. |
| Databáze: | OpenAIRE |
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