Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population
| Autor: | Anne E. Hughes, Weihua Meng, Muhammad S. Kamaruddin, Christopher Patterson, Paul G. Horan, Pascal P. McKeown, Frank Kee, Christine Belton |
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| Rok vydání: | 2007 |
| Předmět: |
Genetic Markers
Male Linkage disequilibrium lcsh:Internal medicine lcsh:QH426-470 Population Single-nucleotide polymorphism Coronary Disease Northern Ireland Biology Polymorphism Single Nucleotide Linkage Disequilibrium Risk Factors Genotype Genetics Humans Genetics(clinical) Age of Onset education lcsh:RC31-1245 Genetics (clinical) education.field_of_study Analysis of Variance Haplotype Genetic Variation Middle Aged Human genetics eye diseases lcsh:Genetics Haplotypes Factor H Complement Factor H sense organs Age of onset Research Article |
| Zdroj: | BMC Medical Genetics BMC Medical Genetics, Vol 8, Iss 1, p 62 (2007) |
| ISSN: | 1471-2350 |
| Popis: | Background The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease. Methods We evaluated 6 SNPs and 5 common haplotypes in the CFH gene amongst 1494 individuals in 580 Irish families with at least one member prematurely affected with coronary heart disease. Genotypes were determined by multiplex SNaPshot technology. Results Using the TDT/S-TDT test, we did not find an association between any of the individual SNPs or any of the 5 haplotypes and early-onset coronary heart disease. Conclusion In this family-based study, we found no association between the CFH gene and early-onset coronary heart disease. |
| Databáze: | OpenAIRE |
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