Comparative Assessment and External Validation of Hepatic Steatosis Formulae in a Community-Based Setting
| Autor: | Dae Won Jun, Myung Sub Kim, Hyun Pyo Hong, Tae Yang Jung, Kyung A Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine magnetic resonance imaging fatty liver Community based Framingham Risk Score medicine.diagnostic_test Receiver operating characteristic business.industry Fatty liver Ultrasound lcsh:R External validation non-alcoholic fatty liver disease Magnetic resonance imaging General Medicine medicine.disease validation study 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology population groups Steatosis business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2851, p 2851 (2020) Volume 9 Issue 9 |
| ISSN: | 2077-0383 |
| Popis: | Several hepatic steatosis formulae have been validated in various cohorts using ultrasonography. However, none of these studies has been validated in a community-based setting using the gold standard method. Thus, the aim of this study was to externally validate hepatic steatosis formulae in community-based settings using magnetic resonance imaging (MRI). A total of 1301 community-based health checkup subjects who underwent liver fat quantification with MRI were enrolled in this study. Diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUROC). Non-alcoholic fatty liver disease (NAFLD) liver fat score showed the highest diagnostic performance with an AUROC of 0.72, followed by Framingham steatosis index (0.70), hepatic steatosis index (HSI, 0.69), ZJU index (0.69), and fatty liver index (FLI, 0.68). There were considerable gray zones in three fatty liver prediction models using two cutoffs (FLI, 28.9% HSI, 48.9% and ZJU index, 53.6%). The diagnostic performance of NAFLD liver fat score for detecting steatosis was comparable to that of ultrasonography. The diagnostic agreement was 72.7% between NAFLD liver fat score and 70.9% between ultrasound and MRI. In conclusion, the NAFLD liver fat score showed the best diagnostic performance for detecting hepatic steatosis. Its diagnostic performance was comparable to that of ultrasonography in a community-based setting. |
| Databáze: | OpenAIRE |
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