Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
| Autor: | Apathsakayan Renugalakshmi, Rodolfo Reda, Mazen F. Alkahtany, Asma Saleh Almeslet, Vikrant R Patil, Ali Robaian, Mohammed Mashyakhy, Thodur Madapusi Balaji, Saranya Varadarajan, Ahmed Alkahtani, Abdulaziz S Abu-Melha, Nassreen Hassan Mohammad Albar, Luca Testarelli, Shankargouda Patil, Shilpa Bhandi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ascorbic acid
cytokines differentiation growth factors mesenchymal stem cells SHEDs stemness Medicine (miscellaneous) Regenerative medicine Article Extracellular matrix 03 medical and health sciences Paracrine signalling 0302 clinical medicine medicine Bone regeneration 030304 developmental biology 0303 health sciences Chemistry Mesenchymal stem cell Osteoblast 030206 dentistry Ascorbic acid Cell biology medicine.anatomical_structure Medicine Stem cell |
| Zdroj: | Journal of Personalized Medicine, Vol 11, Iss 589, p 589 (2021) Journal of Personalized Medicine Volume 11 Issue 7 |
| ISSN: | 2075-4426 |
| Popis: | Stem cells from human exfoliated deciduous teeth (SHEDs) are considered a type of mesenchymal stem cells (MSCs) because of their unique origin from the neural crest. SHEDs can self-renewal and multi-lineage differentiation with the ability to differentiate into odontoblasts, osteoblast, chondrocytes, neuronal cells, hepatocytes, adipocytes, etc. They are emerging as an ideal source of MSCs because of their easy availability and extraordinary cell number. Ascorbic acid, or vitamin C, has many cell-based applications, such as bone regeneration, osteoblastic differentiation, or extracellular matrix production. It also impacts stem cell plasticity and the ability to sustain pluripotent activity. In this study, we evaluate the effects of ascorbic acid on stemness, paracrine secretion, and differentiation into osteoblast, chondrocytes, and adipocytes. SHEDs displayed enhanced multifaceted activity, which may have applications in regenerative therapy. |
| Databáze: | OpenAIRE |
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