Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

Autor: Norman Shreeve, Mike Hollinshead, Hormas Ghadially, Lydia Farrell, Gillian M. Griffiths, Peter Parham, Francesco Colucci, Amir Horowitz, Olympe Chazara, Oisin Huhn, Martin A. Ivarsson, Andrew M. Sharkey, Jakob Theorell, Puran Chen, Ashley Moffett, Lucy Gardner, Jane C. Stinchcombe
Přispěvatelé: Farrell, Lydia E [0000-0002-7643-6009], Griffiths, Gillian [0000-0003-0434-5842], Moffett, Ashley [0000-0002-8388-9073], Sharkey, Andrew M [0000-0002-5072-7748], Colucci, Francesco [0000-0001-5193-6376], Apollo - University of Cambridge Repository, Farrell, Lydia E. [0000-0002-7643-6009], Sharkey, Andrew M. [0000-0002-5072-7748]
Rok vydání: 2021
Předmět:
0301 basic medicine
Chemokine
General Physics and Astronomy
Cell Communication
631/136/3194
Lymphocyte Activation
Mice
0302 clinical medicine
Receptors
KIR
Pregnancy
631/443/494
lcsh:Science
skin and connective tissue diseases
Multidisciplinary
Innate lymphoid cell
Decidua
article
Intrauterine growth
Trophoblasts
Cell biology
Killer Cells
Natural
13/31
medicine.anatomical_structure
Female
Science
Reproductive biology
Innate lymphoid cells
Human leukocyte antigen
Biology
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Immune system
13/21
medicine
Animals
Humans
631/250/2504/2506
Histocompatibility Antigens Class I
Placentation
Dendritic Cells
General Chemistry
Immunity
Innate
Lymphocyte Subsets
Chemokines
C
body regions
Granzyme B
49/1
030104 developmental biology
biology.protein
lcsh:Q
K562 Cells
030215 immunology
XCL1
Zdroj: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DOI: 10.17863/cam.63562
Popis: During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets: decidual NK cells (dNK)1–3, ILC3s and proliferating NK cells. Following stimulation, dNK2 and dNK3 produce more chemokines than dNK1 including XCL1 which can act on both maternal dendritic cells and fetal EVT. In contrast, dNK1 express receptors including Killer-cell Immunoglobulin-like Receptors (KIR), indicating they respond to HLA class I ligands on EVT. Decidual NK have distinctive organisation and content of granules compared with peripheral blood NK cells. Acquisition of KIR correlates with higher granzyme B levels and increased chemokine production in response to KIR activation, suggesting a link between increased granule content and dNK1 responsiveness. Our analysis shows that dILCs are unique and provide specialised functions dedicated to achieving placental development and successful reproduction.
As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.
Databáze: OpenAIRE
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