| Autor: |
Molly J. Goodfellow, Juliana A. Medina, Julie L. Proctor, Su Xu, Rao P. Gullapalli, Parisa Rangghran, Catriona Miller, Alexandra Vesselinov, Gary Fiskum |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of neurotrauma. 39(19-20) |
| ISSN: |
1557-9042 |
| Popis: |
Aeromedical evacuation-relevant hypobaria after traumatic brain injury (TBI) leads to increased neurological injury and death in rats relative to those maintained under normobaria. Applicability of rodent brain injury research to humans may be limited, however, by differences in neuroanatomy. Therefore, we developed a model in which ferrets are exposed to polytrauma consisting of controlled cortical impact TBI and hemorrhagic shock subjected 24 h later to 6 h of hypobaria or normobaria. Our objective was to determine whether the deleterious effects of hypobaria observed in rats, with lissencephalic brains, are also present in a species with a human-like gyrencephalic brain. While no deaths were observed, magnetic resonance spectroscopy (MRS) results obtained two days post-injury indicated reduced cortical creatine |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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