First- and second-line pharmacological treatment for delirium in general hospital setting—Retrospective analysis
| Autor: | Yoshihiro Mifune, Takashi Iwamoto, Yukitaka Morita, Shinji Nojima, Ken Wada |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Drug medicine.medical_specialty media_common.quotation_subject Hospitals General Pharmacological treatment Quetiapine Fumarate 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Humans 030212 general & internal medicine General hospital General Psychology Aged Retrospective Studies media_common Aged 80 and over business.industry Medical record Delirium Trazodone General Medicine Psychiatry and Mental health Tolerability Quetiapine Female medicine.symptom business Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Asian Journal of Psychiatry. 32:50-53 |
| ISSN: | 1876-2018 |
| Popis: | Aim We examined the first- and second-line pharmacological treatment for delirium to determine which drugs were chosen, how and when second-line drugs were started, and the effectiveness and tolerability of those treatments. Methods A retrospective medical chart review was performed for delirium inpatients referred to the Department of Psychiatry, Hiroshima Citizens Hospital, from October 2011 to September 2012. Clinical diagnoses were based on ICD-10. We compared the baseline severity of delirium, duration needed for improvement, and rescue with antipsychotics between subjects given only first-line drugs and those switched to second-line drugs. Results We studied 194 consecutive patients including 127 men and 67 women whose average age was 76.5 ± 9.8 years. For first-line drugs, trazodone was most frequently prescribed (n = 100, 51.5%), followed by quetiapine (n = 57, 29.4%). Among patients treated with trazodone or quetiapine as first line treatment, 59 of 100 (59%) continued trazodone and 52 of 57 (91.2%) continued quetiapine. Duration needed for improvement did not differ significantly between patients treated with trazodone as a first line drug and those with quetiapine as same. Conclusion Trazodone can be a candidate drug as one of the first line drugs for delirium. |
| Databáze: | OpenAIRE |
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