Passage of procaine hydrochloride and para-aminobenzoic acid across the human placenta
Autor: | Michael La Iuppa, Raul Velazco, Frank Moya, Jose E. Usubiaga, Jamie A. Wikinski |
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Rok vydání: | 1968 |
Předmět: |
medicine.medical_specialty
Procaine Hydrochloride Umbilical vein Procaine Anesthesia Conduction Pregnancy Internal medicine Medicine Anesthesia Obstetrical Humans Aminobenzoates Anesthetics Local PARA-AMINOBENZOIC ACID Maternal-Fetal Exchange Fetus business.industry Obstetrics and Gynecology Lidocaine Human placenta Liter Arrhythmias Cardiac Prilocaine Endocrinology Anesthesia Toxicity Injections Intravenous Mepivacaine Female business Methemoglobinemia medicine.drug Adjuvants Anesthesia |
Zdroj: | American journal of obstetrics and gynecology. 100(7) |
ISSN: | 0002-9378 |
Popis: | Maternal and fetal blood levels of procaine and para-aminobenzoic acid were studied following intravenous injection of procaine hydrochloride to the mother during normal delivery. Procaine under 4 mg. per kilogram of body weight did not cross the placental barrier. With larger doses, procaine was found early in th, fdal umbilical vein, reaching a peak concentration of 8.5 µg per milliliter. Para-minobenzoic acid appeared in the fetus following maternal injection of 2 mg. per kilogram of procaine; its blood levels were higher and its peak concerllralions were achieved later than procaine. The infants were born in good condition with Apgar scores ranging from 6 to 10 and unrelated to doses of procaine injected into Ihe mother. No significant signs of toxicity wert observed with the dose used. |
Databáze: | OpenAIRE |
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