Passage of procaine hydrochloride and para-aminobenzoic acid across the human placenta

Autor: Michael La Iuppa, Raul Velazco, Frank Moya, Jose E. Usubiaga, Jamie A. Wikinski
Rok vydání: 1968
Předmět:
Zdroj: American journal of obstetrics and gynecology. 100(7)
ISSN: 0002-9378
Popis: Maternal and fetal blood levels of procaine and para-aminobenzoic acid were studied following intravenous injection of procaine hydrochloride to the mother during normal delivery. Procaine under 4 mg. per kilogram of body weight did not cross the placental barrier. With larger doses, procaine was found early in th, fdal umbilical vein, reaching a peak concentration of 8.5 µg per milliliter. Para-minobenzoic acid appeared in the fetus following maternal injection of 2 mg. per kilogram of procaine; its blood levels were higher and its peak concerllralions were achieved later than procaine. The infants were born in good condition with Apgar scores ranging from 6 to 10 and unrelated to doses of procaine injected into Ihe mother. No significant signs of toxicity wert observed with the dose used.
Databáze: OpenAIRE
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