Asthma in a large COVID-19 cohort: Prevalence, features, and determinants of COVID-19 disease severity
| Autor: | Francesco Menzella, Alessandra Vultaggio, Claudio Micheletto, Emanuele Vivarelli, Andrea Matucci, Andrea Vianello, Gabriella Guarnieri, Ernesto Crisafulli, Gianni Passalacqua, Francesco Almerigogna, Domenico Girelli, Marco Caminati, Oliviero Olivieri, Filippo Cosini, Oliviero Rossi, Laura Pini, Fulvia Chieco-Bianchi, Diego Bagnasco, Gianenrico Senna |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Asthma prevalence Critical Care Short Communication Population Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Internal medicine Severity of illness Prevalence medicine Humans Eosinophilia 030212 general & internal medicine Risk factor COVID-19 outcome education Aged Retrospective Studies Asthma education.field_of_study business.industry Medical record COVID-19 Retrospective cohort study Middle Aged medicine.disease Respiration Artificial Hospitalization Italy 030228 respiratory system COVID-19 susceptibility Cohort Female medicine.symptom business |
| Zdroj: | Respiratory Medicine |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2020.106261 |
| Popis: | Background Asthma prevalence among COVID-19 patients seems to be surprisingly low. However the clinical profile of COVID-19 asthmatic patients and potential determinants of higher susceptibility/worse outcome have been scarcely investigated. We aimed to describe the prevalence and features of asthmatic patients hospitalized for COVID-19 and to explore the association between their clinical asthma profile and COVID-19 severity. Methods Medical records of patients admitted to COVID-Units of six Italian cities major hospitals were reviewed. Demographic and clinical data were analyzed and compared according to the COVID-19 outcome (death/need for ventilation vs discharge at home without requiring invasive procedures). Results Within the COVID-Units population (n = 2000) asthma prevalence was 2.1%. Among the asthmatics the mean age was 61.1 years and 60% were females. Around half of patients were atopic, blood eosinophilia was normal in most of patients. An asthma exacerbation in the 6 months before the Covid-Unit admittance was reported by 18% of patients. 24% suffered from GINA step 4–5 asthma, and 5% were under biologic treatment. 31% of patients were not on regular treatment and a negligible use of oral steroid was recorded. Within the worse outcome group, a prevalence of males was detected (64 vs 29%, p = 0.026); they suffered from more severe asthma (43 vs 14%, p = 0.040) and were more frequently current or former smokers (62 vs 25%, p = 0.038). Conclusions Our report, the first including a large COVID-19 hospitalized Italian population, confirms the low prevalence of asthma. On the other side patients with GINA 4/5 asthma, and those not adequately treated, should be considered at higher risk. Highlights • The prevalence of asthma in a large COVID-19 hospitalized Italian population was low (2.1%). • Male severe asthmatics had a worse COVID-19 outcome. • GINA 4/5 asthma patients, and those not adequately treated, should be considered at higher risk of worse COVID-19 outcome. |
| Databáze: | OpenAIRE |
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