HSP70RY: Further Characterization of a Novel Member of the HSP70 Protein Family
| Autor: | K D, Dyer, M C, Lavigne, H F, Rosenberg |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Protein family
Mrna expression Biophysics Gene Expression Biology Biochemistry Cell Line Mice chemistry.chemical_compound Glutamates Leukemia Promyelocytic Acute Complementary DNA Tumor Cells Cultured Animals Humans HSP70 Heat-Shock Proteins RNA Messenger HSP110 Heat-Shock Proteins Molecular Biology Peptide sequence Heat-Shock Proteins Cell Line Transformed B-Lymphocytes Messenger RNA Sequence Homology Amino Acid Genetic Variation Cell Differentiation Cell Biology Blotting Northern Molecular biology Hsp70 Blotting Southern Sequence homology chemistry Phorbol Tetradecanoylphorbol Acetate |
| Zdroj: | Biochemical and Biophysical Research Communications. 203:577-581 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1994.2221 |
| Popis: | Hsp70RY was identified as a member of the hsp70 protein family on the basis of cDNA sequence homology (Fathallah, et. al. (1993) J. Immunol. 151, 810-813). We have shown that mRNA encoding hsp70RY is expressed in a variety of human cell lines and that mRNA expression remains unchanged in human promyelocytic HL-60 cells induced to differentiate with phorbol 12-myristate 13-acetate (PMA). We have also shown that the predicted amino acid sequence of hsp70RY diverges significantly from the other human hsp70 proteins and that it contains a unique glutamate-rich region near its carboxy-terminus. Finally, we have demonstrated the existence of a murine homolog of hsp70RY. |
| Databáze: | OpenAIRE |
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