Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy

Autor:	Ayodeji A. Olabiyi, Ganiyu Oboh, Daniela B.R. Leal, Stephen A. Adefegha, Lívia G. Castilhos
Rok vydání:	2017
Předmět:	0301 basic medicine Physiology Thiobarbituric acid Clinical Biochemistry Anti-Inflammatory Agents Pharmacology Biochemistry Thiobarbituric Acid Reactive Substances Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Hesperidin 0302 clinical medicine TBARS Animals Rats Wistar Pleurisy Research Articles Peroxidase chemistry.chemical_classification Inflammation Reactive oxygen species biology Superoxide Dismutase Biochemistry (medical) Porphobilinogen Synthase Cell Biology Catalase Glutathione Carrageenan Rats Oxidative Stress 030104 developmental biology chemistry Liver 030220 oncology & carcinogenesis Myeloperoxidase biology.protein Reactive Oxygen Species
Zdroj:	Redox Rep
ISSN:	1743-2928
Popis:	Objectives: This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model. Methods: Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation control group); Group III: rats were administered hesperidin only (Hesperidin group); Group IV: rats were administered hesperidin orally and intrapleurally injected with 2% carrageenan (Inflammation treated with hesperidin group). The exudate volume, total leukocyte count, reactive oxygen species (ROS), myeloperoxidase (MPO),δ–aminolevulinate dehydratase (δ-ALA-D), catalase (CAT), superoxide dismutase (SOD), activities as well as non-protein thiol group (NPSH) and thiobarbituric acid reactive substances (TBARS) levels were determined. Results: Pretreatment with hesperidin at a dose of 80 mg/kg orally per day for 21 days, minimized the increase in pleural exudate volume and leucocyte count and modulated the activities of MPO, SOD and CAT, as well as the levels of ROS, NPSH and TBARS in carrageenan-induced rats. Conclusion: Our results suggest that hesperidin can elicit its anti-inflammatory action by blocking exudate and leukocyte influx into pleural cavity, inhibiting MPO activity and preventing oxidative damage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ae4f6bed87b697adf8316e34556864 https://pubmed.ncbi.nlm.nih.gov/28657497 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.