Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
| Autor: | Isabela Werneck da Cunha, Rafael Malagoli Rocha, Fernando Augusto Soares, André Lopes Carvalho, Fernanda Rocha Rojas Ayala, Katia C. Carvalho, Silvia Vanessa Lourenço |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty endocrine system Pharmaceutical Science Article Analytical Chemistry oral carcinoma lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Immunochemistry medicine Carcinoma Biomarkers Tumor Humans Physical and Theoretical Chemistry Aged Mouth neoplasm Aged 80 and over Glucose Transporter Type 1 Tissue microarray biology Glucose Transporter Type 3 Organic Chemistry Middle Aged medicine.disease Prognosis Staining carbohydrates (lipids) Chemistry (miscellaneous) immunohistochemistry biology.protein Carcinoma Squamous Cell Molecular Medicine Immunohistochemistry GLUT1 Female Mouth Neoplasms GLUT3 hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecules Molecules, Vol 15, Iss 4, Pp 2374-2387 (2010) Molecules; Volume 15; Issue 4; Pages: 2374-2387 |
| ISSN: | 1420-3049 |
| Popis: | We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Methods: Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells. Results: GLUT 1 was over expressed in 50.3% of OSSC cases showing membrane staining pattern. However, nuclear expression was observed in 49.7% of the analyzed cases. GLUT 3 over expression was detected in 21.1% of OSCC cases. The pattern of GLUT 1 expression showed significant association with alcohol consumption (p = 0.004). Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Conclusion: GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. |
| Databáze: | OpenAIRE |
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