Clinical implications of isolated troponinemia following immune checkpoint inhibitor therapy
| Autor: | Marc Peeters, Hans Prenen, F. Gremonprez, Christof Vulsteke, D. Delombaerde, C. Franssen, Lieselot Croes, D. Vervloet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Myocarditis medicine.medical_treatment cardiotoxicity Review Asymptomatic Internal medicine Neoplasms cardiac troponin medicine Humans cancer Clinical significance Adverse effect Immune Checkpoint Inhibitors Cardiotoxicity biology business.industry Immunotherapy medicine.disease Troponin biology.protein Biomarker (medicine) biomarker immunotherapy Human medicine medicine.symptom business |
| Zdroj: | ESMO Open |
| ISSN: | 2059-7029 |
| Popis: | Cardiovascular adverse events induced by immune checkpoint inhibitors (ICIs) have gained significant interest over the past decade due to their impact on short- and long-term outcomes. They were initially thought to be rare, but the increasing use of ICIs in the treatment of both advanced and early stages of various malignancies has resulted in a substantial increase in their incidence. Different guidelines have proposed screening measures for ICI-induced myocarditis by incorporating troponin measurements at baseline and during the first few weeks of treatment. However, no specific guidelines have been developed yet regarding the interpretation of an asymptomatic rise in troponins. This state-of-the art review aims to provide an overview of the clinical relevance of elevated troponins during checkpoint inhibition and recommendations on how to manage elevated troponin levels during ICI therapy. Highlights • The clinical interpretation and implication of troponin levels remain unclear. • Many mechanisms can contribute to an asymptomatic increase in troponinemia. • Conditions are urgently needed to correctly interpret troponin results. • Prospective studies are needed before recommending troponin surveillance as a standard of care. |
| Databáze: | OpenAIRE |
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