Polymorphisms of Platelet Glycoprotein Receptors and Cell Adhesion Molecules in Fetuses with Fetal Growth Restriction and Their Mothers As Detected with Pyrosequencing
| Autor: | Emmanuel Economou, Maria Simou, Evaggelia Kouskouni, Nikolaos Vitoratos, George Creatsas |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Cancer Research P-selectin Genotype Integrin alpha2 Mothers Single-nucleotide polymorphism Platelet Membrane Glycoproteins Biology Platelet membrane glycoprotein Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Andrology 03 medical and health sciences 0302 clinical medicine Fetus Gene Frequency Humans Platelet Prospective Studies Receptor G alpha subunit 030203 arthritis & rheumatology Pharmacology Fetal Growth Retardation Cell adhesion molecule Integrin beta3 Sequence Analysis DNA Molecular biology Platelet Endothelial Cell Adhesion Molecule-1 P-Selectin 030104 developmental biology Logistic Models Female Cell Adhesion Molecules Research Article |
| Popis: | Background Vascular thrombotic tendency may lead to fetal growth restriction (FGR). Altered platelet function and genetic heterogeneity may play a role in this procedure. We investigated whether maternal or fetal genotypic frequencies of genes polymorphisms for certain platelet receptor and cell adhesion molecules are altered in FGR. Materials and methods We compared the maternal and fetal genotypic frequencies of single nucleotide polymorphisms (SNPs) in four genes coding for platelet receptors and cell adhesion molecules [integrin alpha subunit 2 (ITGA2)C807T, integrin subunit beta 3(ITGB3) T1565C, platelet cell adhesion protein 1 (PECAM1) CTG-GTG and selectin P(SELP)A/C]. A total of 32 fetuses with fetal growth restriction and their mothers were matched with 18 normal controls. Using maternal venous blood and umbilical cord blood samples, nucleotide sequences were determined from pyrograms. Genotypic frequencies were calculated and analyzed using appropriate tests and logistic regression. Results There was no statistical difference in the proportion of heterozygotes or homozygotes for any of the genotypic frequencies between FGR and control groups in mothers or fetuses. Conclusion Our study demonstrated no association of maternal or fetal ITGA2 C807T SNP, ITGB3 T1565C SNP, PECAM1 CTG - GTG and SELP A/C polymorphisms with FGR. |
| Databáze: | OpenAIRE |
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