A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules
| Autor: | N. S. Hari Narayana Moorthy, Ruchi Bansal, Dhirendra Pratap Singh, Piyush Trivedi, Karthikeyan Chandrabose, Digvijay Singh |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Chemistry(all) Chemistry Coefficient of variation 010401 analytical chemistry Assay General Chemistry Capsule Dosage Form 010402 general chemistry 01 natural sciences High-performance liquid chromatography Isocratic 0104 chemical sciences lcsh:Chemistry Chromatographic separation lcsh:QD1-999 Validation medicine Ziprasidone hydrochloride monohydrate Ziprasidone Ziprasidone Hydrochloride HPLC Routine analysis Capsule medicine.drug |
| Zdroj: | Journal of Saudi Chemical Society, Vol 20, Iss S1, Pp S161-S167 (2016) |
| ISSN: | 1319-6103 |
| DOI: | 10.1016/j.jscs.2012.10.005 |
| Popis: | In this work, a new isocratic reverse phase chromatographic method was developed using HPLC for ziprasidone hydrochloride monohydrate (ZHM). The newly developed method is applicable for assay determination of the ZHM in capsule dosage form. The chromatographic separation of ZHM was achieved on a Zorbax SB C-8 (50 × 4.6) mm, 3.5 μm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability. The satisfying recoveries (98–100%) and low coefficient of variation confirmed the suitability of the proposed method for the routine analysis of ZHM in pharmaceuticals. |
| Databáze: | OpenAIRE |
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