Phase II studies of 4'-iodo-4'-deoxydoxorubicin in advanced non-small cell lung, colon and breast cancers
| Autor: | T. Skovsgaard, P. Liati, S. B. Kaye, R. Sorio, F. Calabresi, Cristiana Sessa, Franco Cavalli, Thomas Cerny |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Lung Neoplasms Anthracycline medicine.medical_treatment Phases of clinical research Breast Neoplasms Granulocyte Breast cancer Internal medicine Carcinoma Non-Small-Cell Lung Medicine Humans Aged Chemotherapy Lung business.industry Hematology Middle Aged medicine.disease Chemotherapy regimen medicine.anatomical_structure Doxorubicin Toxicity Colonic Neoplasms Drug Evaluation Female business Agranulocytosis |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 2(10) |
| ISSN: | 0923-7534 |
| Popis: | Summary The new anthracycline analogue, 4’-iodo-4’-deoxydoxorubicin (I-DOX), was administered at 70 mg/m2 as first chemotherapy in 61 patients with advanced NSCL (19), colon (20) and breast cancers (22). Treatment was repeated every 3 weeks; the dose was decreased to 60 mg/m2(19% of the cycles) or increased to 80 mg/m2 (17% of the cycles) according to the granulocyte count nadir. Partial responses were observed in 6% of the patients with NSCL, in 5.5% of those with colon and in 10% of those with breast cancers. The main toxicity was a selective granulocytopenia characterized by a duration of about 1 week, and a high inter-patient variability. Non-haematological toxicities were mild. The negative results obtained in breast cancer might be related to the dose administered. Further studies in this tumour type should be performed with a more aggressive schedule. |
| Databáze: | OpenAIRE |
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