White Adipose Tissue Surface Expression of LDLR and CD36 is Associated with Risk Factors for Type 2 Diabetes in Adults with Obesity
Autor: | Yannick Cyr, Emmanuelle Loizon, Gaétan Mayer, Valérie Lamantia, Emilienne Tudor Ngo Sock, Simon Bissonnette, Hubert Vidal, Michel Chrétien, Hanny Wassef, May Faraj |
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Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Canadian Institutes of Health Research (CIHR)13359893581123409 |
Rok vydání: | 2020 |
Předmět: |
CD36 Antigens
Male medicine.medical_specialty Diabetes risk Apolipoprotein B Adipose Tissue White Endocrinology Diabetes and Metabolism CD36 Medicine (miscellaneous) Adipose tissue 030209 endocrinology & metabolism White adipose tissue 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Risk Factors Internal medicine medicine Humans Obesity 030212 general & internal medicine Aged Nutrition and Dietetics biology business.industry food and beverages nutritional and metabolic diseases [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged Postprandial Period medicine.disease Cross-Sectional Studies Postprandial Diabetes Mellitus Type 2 Receptors LDL LDL receptor biology.protein Female lipids (amino acids peptides and proteins) business hormones hormone substitutes and hormone antagonists |
Zdroj: | Obesity Obesity, Wiley, 2020, 28 (12), pp.2357-2367. ⟨10.1002/oby.22985⟩ |
ISSN: | 1930-739X 1930-7381 |
Popis: | International audience; Objective Human conditions with upregulated receptor uptake of low-density lipoproteins (LDL) are associated with diabetes risk, the reasons for which remain unexplored. LDL induce metabolic dysfunction in murine adipocytes. Thus, it was hypothesized that white adipose tissue (WAT) surface expression of LDL receptor (LDLR) and/or CD36 is associated with WAT and systemic metabolic dysfunction. Whether WAT LDLR and CD36 expression is predicted by plasma lipoprotein-related parameters was also explored. Methods This was a cross-sectional analysis of 31 nondiabetic adults (BMI > 25 kg/m(2)) assessed for WAT surface expression of LDLR and CD36 (immunohistochemistry), WAT function, WAT and systemic inflammation, postprandial fat metabolism, and insulin resistance (IR; hyperinsulinemic-euglycemic clamp). Results Fasting WAT surface expression of LDLR and CD36 was negatively associated with WAT function (H-3-triglyceride storage,r = -0.45 and -0.66, respectively) and positively associated with plasma IL-1 receptor antagonist (r = 0.64 and 0.43, respectively). Their expression was suppressed 4 hours postprandially, and reduced LDLR was further associated with IR (M/I-clamp,r = 0.61 women,r = 0.80 men). Plasma apolipoprotein B (apoB)-to-PCSK9 ratio predicted WAT surface expression of LDLR and CD36, WAT dysfunction, WAT NLRP3 inflammasome priming and disrupted cholesterol-sensing genes, and systemic IR independent of sex and body composition. Conclusions Higher fasting and lower postprandial WAT surface expression of LDLR and CD36 is associated with WAT dysfunction, systemic inflammation, and IR in adults with overweight/obesity, anomalies that are predicted by higher plasma apoB-to-PCSK9 ratio. |
Databáze: | OpenAIRE |
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