Predictive value of sFlt-1, PlGF, sFlt-1/PlGF ratio and PAPP-A for late-onset preeclampsia and IUGR between 32 and 37 weeks of pregnancy
| Autor: | Mirjam Frank, L. Droste, Börge Schmidt, J. Fryze, A Enekwe, Angela Köninger, Cahit Birdir, Rainer Kimmig, L. Fox, Alexandra Gellhaus |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Placental growth factor medicine.medical_specialty Pregnancy Trimester Third Medizin Intrauterine growth restriction 030204 cardiovascular system & hematology Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Predictive Value of Tests Pregnancy Risk Factors Internal Medicine medicine Humans Pregnancy-Associated Plasma Protein-A Prospective Studies Prospective cohort study Placenta Growth Factor Fetal Growth Retardation Vascular Endothelial Growth Factor Receptor-1 030219 obstetrics & reproductive medicine Obstetrics business.industry Area under the curve Obstetrics and Gynecology Gestational age Prognosis medicine.disease ROC Curve Area Under Curve Case-Control Studies embryonic structures Linear Models Female business Biomarkers Blood sampling |
| Zdroj: | Pregnancy Hypertension. 12:124-128 |
| ISSN: | 2210-7789 |
| DOI: | 10.1016/j.preghy.2018.04.010 |
| Popis: | Objectives The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. Methods This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32–37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy. 22 patients developed IUGR, 32 PE and 24 PIH. Results Linear regression analyses after adjusting for maternal age, gestational age at the blood sampling and maternal BMI showed associations between PE and serum sFlt-1 levels (Exp(s) = 3.29; 95% CI: 2.69–4.04), serum PlGF levels (Exp(s) = 0.18; 95% CI: 0.13–0.24), sFlt-1/PlGF ratio (Exp(s) = 15.59; 95% CI: 10.64–22.84) and serum PAPP-A (Exp(s) = 1.48; 95% CI 1.15–1.89). sFlt-1, PlGF and sFlt-1/PlGF-Ratio showed comparable area under the curve (AUC) estimates with a predictive ability to discriminate pregnancies developing PE and IUGR from controls. The predictive ability of PAPP-A for PE was only slightly better than chance. Conclusions This study supported the ability of a single measurement of sFlt-1/PlGF ratio at third trimester to predict PE and IUGR occurring after 34 weeks of pregnancy. However, larger multicentre studies are needed to replicate our results. |
| Databáze: | OpenAIRE |
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