The SLP-76 family of adapter proteins
| Autor: | Gary A. Koretzky, Jennifer N. Wu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Immunology
Integrin Signal transducing adaptor protein Biology Phosphoproteins Cell biology Lymphatic System src Homology Domains Adapter (genetics) Phosphoprotein Leukocytes biology.protein Animals Humans Immunology and Allergy Signal transduction Carrier Proteins Receptor B-Cell Linker Protein Linker Adaptor Proteins Signal Transducing Signal Transduction |
| Zdroj: | Seminars in Immunology. 16:379-393 |
| ISSN: | 1044-5323 |
| DOI: | 10.1016/j.smim.2004.08.018 |
| Popis: | Adapter molecules are multidomain proteins lacking intrinsic catalytic activity, functioning instead by nucleating molecular complexes during signal transduction. The SLP-76 family of adapters includes SH2 domain-containing leukocyte phosphoprotein of 76kDa (SLP-76), B cell linker protein (BLNK), and cytokine-dependent hematopoietic cell linker (Clnk). These proteins are critical for integration of numerous signaling cascades downstream of immunotyrosine-based activation motif (ITAM)-bearing receptors and integrins in diverse hematopoietic cell types. Mutations in genes encoding SLP-76 family adapters result in severe phenotypes, underscoring the critical role these proteins play in cellular development and function by directing formation of signaling complexes in a temporally- and spatially-specific manner. |
| Databáze: | OpenAIRE |
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