Outcomes and long-term effects of COVID-19 in patients with inflammatory bowel diseases - a Danish prospective population-based cohort study with individual-level data

Autor: Mohamed Attauabi, Klaus Theede, Lone Heimann Larsen, Tine Jess, Michael Dam Jensen, August Pilegaard Prahm, Asser Mathiassen Oppfeldt, Malte Rosager Hansen, Jakob Benedict Seidelin, Natalia Pedersen, Sule Eraslan, Marianne Kiszka-Kanowitz, Johan Burisch, Marianne Kajbæk Verner-Andersen, Anja Poulsen, Anders Berg Lødrup, Jens Frederik Dahlerup, Henning Glerup, Akbar Molazahi, Anders Neumann, Kent V. Haderslev
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Attauabi, M, Dahlerup, J F, Poulsen, A, Hansen, M R, Verner-Andersen, M K, Eraslan, S, Prahm, A P, Pedersen, N, Larsen, L, Jess, T, Neumann, A, Haderslev, K V, Molazahi, A, Lødrup, A B, Glerup, H, Oppfeldt, A M, Jensen, M D, Theede, K, Kiszka-Kanowitz, M, Seidelin, J B, Burisch, J & the Danish COVID-IBD Study Group 2022, ' Outcomes and long-term effects of COVID-19 in patients with inflammatory bowel diseases-a Danish prospective population-based cohort study with individual-level data ', Journal of Crohn's & colitis, vol. 16, no. 5, jjab192, pp. 757–767 . https://doi.org/10.1093/ecco-jcc/jjab192
Attauabi, M, Dahlerup, J F, Poulsen, A, Hansen, M R, Vester-Andersen, M K, Eraslan, S, Prahm, A P, Pedersen, N, Larsen, L, Jess, T, Neumann, A, Haderslev, K V, Molazahi, A, Lødrup, A B, Glerup, H, Oppfeldt, A M, Jensen, M D, Theede, K, Kiszka-Kanowitz, M, Seidelin, J B, Burisch, J & Danish COVID-IBD Study Group 2022, ' Outcomes and Long-Term Effects of COVID-19 in Patients with Inflammatory Bowel Diseases-A Danish Prospective Population-Based Cohort Study with Individual-Level Data ', Journal of Crohn's & colitis, vol. 16, no. 5, pp. 757-767 . https://doi.org/10.1093/ecco-jcc/jjab192
Journal of Crohn's & Colitis
DOI: 10.1093/ecco-jcc/jjab192
Popis: Background and Aims The health consequences of coronavirus disease 2019 [COVID-19] among patients with ulcerative colitis [UC] and Crohn’s disease [CD] remain largely unknown. We aimed to investigate the outcomes and long-term effects of COVID-19 in patients with UC or CD. Methods We conducted a prospective, population-based study covering all Danish patients with CD or UC and confirmed COVID-19 between January 28, 2020 and April 1, 2021, through medical records and questionnaires. Results All 319 patients with UC and 197 patients with CD who developed COVID-19 in Denmark were included in this study and compared with the Danish background population with COVID-19 [N = 230 087]. A significantly higher risk of COVID-19-related hospitalization was observed among patients with UC (N = 46 [14.4%], relative risk [RR] = 2.49 [95% confidence interval, CI, 1.91–3.26]) and CD (N = 24 [12.2%], RR = 2.11 [95% CI 1.45–3.07]) as compared with the background population (N = 13 306 [5.8%]). A similar pattern was observed for admission to intensive care (UC: N = 8 [2.51%], RR = 27.88 [95% CI 13.88–56.00]; CD: N = 3 [1.52%], RR = 16.92 [95% CI 5.46–52.46]). After a median of 5.1 months (interquartile range [IQR] 4.5–7.9), 58 [42.3%] and 39 [45.9%] patients with UC and CD, respectively, reported persisting symptoms which were independently associated with discontinuation of immunosuppressive therapies during COVID-19 (odds ratio [OR] = 1.50 [95% CI 1.07–10.22], p = 0.01) and severe COVID-19 (OR = 2.76 [95% CI 1.05–3.90], p = 0.04), but not with age or presence of comorbidities. Conclusion In this population-based study of 516 patients with IBD and COVID-19, 13.6% needed hospitalization and 2.1% required intensive care. Furthermore, sequelae were frequent, affecting 43.7% of COVID-19-infected patients. These findings might have implications for planning the healthcare of patients in the post-COVID-19 era.
Databáze: OpenAIRE
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