Quantification of Abdominal Aortic Aneurysm Stiffness using Magnetic Resonance Elastography and its Comparison to Aneurysm Diameter
| Autor: | Arunark Kolipaka, William Kenyhercz, Jean E. Starr, Richard D. White, Venkata Sita Priyanka Illapani, Patrick S. Vaccaro, Michael R. Go, Joshua D. Dowell |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Computed Tomography Angiography 030204 cardiovascular system & hematology environment and public health Magnetic resonance angiography 030218 nuclear medicine & medical imaging Aortic aneurysm 0302 clinical medicine Risk Factors Aorta Abdominal medicine.diagnostic_test Middle Aged Prognosis Abdominal aortic aneurysm cardiovascular system Elasticity Imaging Techniques Female Radiology Cardiology and Cardiovascular Medicine Dilatation Pathologic Adult medicine.medical_specialty Aortography Aortic Rupture macromolecular substances Article Statistics Nonparametric 03 medical and health sciences Aneurysm Vascular Stiffness Predictive Value of Tests medicine.artery medicine Humans cardiovascular diseases Aortic rupture Vascular Calcification Aged Aorta business.industry Thrombosis medicine.disease Magnetic resonance elastography enzymes and coenzymes (carbohydrates) Case-Control Studies Surgery business Magnetic Resonance Angiography Aortic Aneurysm Abdominal |
| Popis: | Objective Abdominal aortic aneurysm (AAA) wall stiffness has been suggested to be an important factor in the overall rupture risk assessment compared with anatomic measure. We hypothesize that AAA diameter will have no correlation to AAA wall stiffness. The aim of this study is to (1) determine magnetic resonance elastography (MRE)-derived aortic wall stiffness in AAA patients and its correlation to AAA diameter; (2) determine the correlation between AAA stiffness and amount of thrombus and calcium; and (3) compare the AAA stiffness measurements against age-matched healthy individuals. Methods In vivo abdominal aortic MRE was performed on 36 individuals (24 patients with AAA measuring 3-10 cm and 12 healthy volunteers), aged 36 to 78 years, after obtaining written informed consent under the approval of the Institutional Review Board. MRE images were processed to obtain spatial stiffness maps of the aorta. AAA diameter, amount of thrombus, and calcium score were reported by experienced interventional radiologists. Spearman correlation, Wilcoxon signed rank test, and Mann-Whitney test were performed to determine the correlation between AAA stiffness and diameter and to determine the significant difference in stiffness measurements between AAA patients and healthy individuals. Results No significant correlation ( P > .1) was found between AAA stiffness and diameter or amount of thrombus or calcium score. AAA stiffness (mean 13.97 ± 4.2 kPa) is significantly ( P ≤ .02) higher than remote normal aorta in AAA (mean 8.87 ± 2.2 kPa) patients and in normal individuals (mean 7.1 ± 1.9 kPa). Conclusions Our results suggest that AAA wall stiffness may provide additional information independent of AAA diameter, which may contribute to our understanding of AAA pathophysiology, biomechanics, and risk for rupture. |
| Databáze: | OpenAIRE |
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