Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM
| Autor: | R. M. Wilson, Gordon W. Duff, C M Artlett, J. D. Ward, Anthony G. Wilson, A M Gonzalez, Ken I. Welsh, Angela Cox |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Linkage disequilibrium Genotype endocrine system diseases Endocrinology Diabetes and Metabolism Molecular Sequence Data HLA-DR3 Biology Major histocompatibility complex Polymerase Chain Reaction HLA-DR3 Antigen Gene Frequency Reference Values Diabetes mellitus Odds Ratio Internal Medicine medicine Humans Age of Onset Allele Allele frequency Alleles DNA Primers Base Sequence Tumor Necrosis Factor-alpha Histocompatibility Testing HLA-DR1 Antigen Odds ratio medicine.disease Diabetes Mellitus Type 1 Haplotypes Immunology biology.protein |
| Zdroj: | Diabetologia. 37:500-503 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s001250050138 |
| Popis: | Insulin-dependent diabetes mellitus (IDDM) is associated with class II molecules of the MHC on chromosome 6, in particular HLA-DR and -DQ al-leles, but a pathogenic role for TNF-a in the class III region of the MHC has also been implied. We therefore tested whether there was any independent association between a biallelic TNF polymorphism and IDDM. The TNF2 allele was present in 61 of 114 (54 %) IDDM patients compared to 101 of 253 (40 %) control subjects (odds ratio 1.73; p > 0.02). Stratification analysis in individuals matched for HLA-DR3 revealed, however, that this association was not independent of HLA-DR3 and is most likely to be a result of linkage disequilibrium between these alleles. |
| Databáze: | OpenAIRE |
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