5-HT(2A/2C) receptor-mediated hypopnea in the newborn rat: relationship to Fos immunoreactivity
| Autor: | Florence Cayetanot, Nicole Larnicol, Françoise Gros |
|---|---|
| Přispěvatelé: | Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers (ECOTROP), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales (LBVPAM), Université Jean Monnet [Saint-Étienne] (UJM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales (BVPAM), Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Agonist
medicine.medical_specialty MESH: Receptors Serotonin MESH: Rats medicine.drug_class MESH: Neurons Ritanserin Biology MESH: Animals Newborn MESH: Sleep Apnea Syndromes Catecholamines Sleep Apnea Syndromes Internal medicine Receptor Serotonin 5-HT2C medicine MESH: Catecholamines Animals Receptor Serotonin 5-HT2A MESH: Animals [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Receptor 5-HT receptor Neurons MESH: Respiration MESH: Serotonin Agonists Tyrosine hydroxylase MESH: Proto-Oncogene Proteins c-fos MESH: Receptor Serotonin 5-HT2C Respiration MESH: Receptor Serotonin 5-HT2A MESH: Immunohistochemistry Rostral ventrolateral medulla Immunohistochemistry Rats Serotonin Receptor Agonists Endocrinology Animals Newborn Receptors Serotonin Pediatrics Perinatology and Child Health Medulla oblongata Catecholaminergic cell groups Proto-Oncogene Proteins c-fos medicine.drug |
| Zdroj: | Pediatric Research Pediatric Research, Nature Publishing Group, 2001, 50 (5), pp.596-603 Pediatric Research, 2001, 50 (5), pp.596-603 |
| ISSN: | 0031-3998 1530-0447 |
| Popis: | Previous data derived from anesthetized, decerebrate, or in vitro preparations suggested that 5-HT(2) receptor activation might be responsible for respiratory dysfunction. Such a mechanism has not yet been documented in the intact animal, but might be of clinical relevance to the apneic spells of the premature infant. In the present investigation on conscious newborn rats we analyzed the respiratory response to the activation of 5-HT(2A/2C) receptors by the agonist 1-(2.5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), and we delineated central structures possibly involved in this response, using Fos expression as a marker of neuronal activation. We demonstrated that intraperitoneal injection of 5 mg/kg DOI produced a long-lasting decrease in respiratory frequency and tidal volume, which could be blocked by the antagonist ritanserin. Fos immunohistochemistry suggested that the rostral ventrolateral medulla and the lateral paragigantocellular nucleus might have a key role in the respiratory response to 5-HT(2) receptor activation. In addition, double immunostaining for Fos and tyrosine hydroxylase suggested that the contribution of catecholaminergic neurons to this response might be modest and indirect. |
| Databáze: | OpenAIRE |
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