Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
| Autor: | Malcom Maden, Michael J. Wolfgang, Guang Hu, Hao Zhang, Rochelle Buffenstein, Guo N. Huang, Emily Wilson, Michael M. Yartsev, Luke I. Szweda, Ellen Gillett, Dominic Lunn, Sandra E Muroy, Stephen Cutie, Frédéric Flamant, Rachel B. Bigley, DeeAnn M. Reeder, Kenneth A. Field, Jeffrey E. Olgin, Tobias A. Schmid, Megan Smith, Kentaro Hirose, Jiajia Wang, Romain Guyot, Thomas S. Scanlan, Alison Hoang, Alexander Y. Payumo, Frank Grützner, Hongyao Yu |
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| Přispěvatelé: | Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, Dominican University of California, Department of Medicine, Division of Cardiology, University of California [San Francisco] (UCSF), University of California-University of California-University of California [San Francisco] (UCSF), University of California-University of California, Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Calico Life Sciences, School of Biological Sciences, University of South Australia [Adelaide], Department of Molecular and Cell Biology, University of California [Berkeley], Helen Wills Neuroscience Institute and Department of Bioengineering, Department of Biology, Bucknell University, Department of Biology and UF Genetics Institute, University of Florida [Gainesville], Department of Biological Chemistry, Johns Hopkins University School of Medicine [Baltimore], Department of Physiology and Pharmacology, Oregon State University (OSU), University of Texas Southwestern Medical Center, JSPS Overseas Research Fellowships UCSF-IRACDA postdoctoral fellowship NIGMS IMSD fellowship Hillblom fellowship Australian Research Council French National Research Agency (ANR)ANR-15-CE14-0011-01United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS)1ZIAES102745United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USAR01HL13845R00HL114738Edward Mallinckrodt Jr. Foundation March of Dimes Basil O'Conner Scholar Award American Heart Association American Federation for Aging Research Life Sciences Research Foundation Program for Breakthrough Biomedical Research UCSF Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Seed Grant UCSF Academic Senate Committee on Research REAC Award (Harris Fund) United States Department of Defense Cardiovascular Research Institute, École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), University of Florida [Gainesville] (UF), University of California (UC), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC)-University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), University of California [Berkeley] (UC Berkeley), National Institute of Environmental Health Sciences, National Institutes of Health, Life Sciences, University of Adelaide, Johns Hopkins University, School of Medicine, Oregon Health & Science University |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Newt [SDV]Life Sciences [q-bio] Proliferation 030204 cardiovascular system & hematology Cardiovascular Regenerative Medicine Mice [SPI]Engineering Sciences [physics] 0302 clinical medicine Receptors Thyroid Hormone 2.1 Biological and endogenous factors Myocyte Myocytes Cardiac Aetiology Receptor Zebrafish Phylogeny Multidisciplinary Receptors Thyroid Hormone Thyroid Temperature Heart Lizards Cell biology Cardiovascular physiology Heart Disease medicine.anatomical_structure Signal transduction Cardiac Body Temperature Regulation Signal Transduction Thyroid Hormones Consumption General Science & Technology Activation Biology Energy-expenditure Article Polyploidy 03 medical and health sciences medicine Animals Regeneration [INFO]Computer Science [cs] Cell Proliferation Myocytes Regeneration (biology) Cell Cycle Checkpoints biology.organism_classification Diploidy Recombination 030104 developmental biology Metabolic-rate Hormone |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩ Circ Res Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩ Science, American Association for the Advancement of Science, 2019, 364 (6436), pp.184-188. ⟨10.1126/science.aar2038⟩ Science (New York, N.Y.), vol 364, iss 6436 |
| ISSN: | 0036-8075 1095-9203 |
| Popis: | The price of staying warm Among vertebrates, zebrafish and salamanders can regenerate their hearts, whereas adult mice and humans cannot. Hirose et al. analyzed diploid cardiomyocyte frequency as a proxy for cardiac regenerative potential across 41 vertebrate species (see the Perspective by Marchianò and Murry). They observed an inverse correlation of these cells with thyroid hormone concentrations during the ectotherm-to-endotherm transition. Mice with defects in thyroid hormone signaling retained significant heart regenerative capacity, whereas zebrafish exposed to excessive thyroid hormones exhibit impaired cardiac repair. Loss of heart regenerative ability in mammals may represent a trade-off for increases in metabolism necessary for the development of endothermy. Science , this issue p. 184 ; see also p. 123 |
| Databáze: | OpenAIRE |
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